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IL21 — IL6
Text-mined interactions from Literome
Shinoda et al., Cell Signal 1999
:
C2-ceramide did not affect the
IL-6 synthesis
induced by
interleukin-1
Albanesi et al., J Invest Dermatol 2000
(Dermatitis, Allergic Contact...) :
In addition,
interleukin-17 stimulated the release of growth regulated oncogene-alpha, granulocyte-macrophage colony stimulating factor, and
interleukin-6 , with synergistic or additive effects when used together with interferon-gamma or interleukin-4
Ishikawa et al., Jpn J Vet Res 2001
:
Brain
interleukin-1 is
involved in blood
interleukin-6 response to immobilization stress in rats
Andoh et al., Biochim Biophys Acta 2002
:
In human pancreatic myofibroblasts,
interleukin (IL)-17 markedly
enhances tumor necrosis factor (TNF)-alpha induced
IL-6 secretion through the induction of IL-6 mRNA stabilization
Yamamoto et al., Arthritis Rheum 2003
(Arthritis, Experimental...) :
The effects of RasDN overexpression on cellular proliferation,
interleukin-1 (IL-1) induced
activation of mitogen activated protein kinases ( extracellular signal regulated kinase [ ERK ], p38, c-Jun N-terminal kinase [ JNK ] ), and
IL-6 production by synovial cells were analyzed
Planck et al., Invest Ophthalmol Vis Sci 1992
:
Retinal pigment epithelial cells secrete
interleukin-6 in
response to
interleukin-1
Shimizu et al., Arch Oral Biol 1992
:
Stimulation by
interleukin-1 of
interleukin-6 production by human periodontal ligament cells
Nishitai et al., J Biol Chem 2004
:
Instead,
interleukin-1 beta (IL-1 beta)
induced IL-6 gene expression was greatly suppressed in sek1 ( -/- ) mkk7 ( -/- ) fibroblasts
Saito et al., Mech Ageing Dev 2003
(Endotoxemia...) :
The stress mediated induction of interleukin-1beta,
interleukin-6 , and interleukin-10 ( IL-1beta, IL-6, and IL-10 ) in the circulating blood tended to be higher with aging in both CLP and LPS models, and in particular, the induction of
IL-6 was significantly
augmented with aging
Silfverswärd et al., J Orthop Res 2004
:
Interleukin-4 and interleukin-13 potentiate
interleukin-1 induced secretion of
interleukin-6 in human osteoblast-like cells
Nesbitt et al., Mol Biol Cell 1992
(Inflammation) :
We employed ribonuclease protection assays to measure the expression of
IL-6-R and gp130 mRNA in primary rat hepatocytes in
response to IL-6,
interleukin-1 , dexamethasone, and combinations thereof
Méndez-Dávila et al., J Endocrinol Invest 2004
(Osteoporosis) :
We investigated the effects of 17betaestradiol and two selective estrogen receptor modulators, tamoxifen and raloxifene, on the expression and release of constitutive and
interleukin-1 stimulated
interleukin (IL)-6 , transforming growth factor-beta1 ( TGF-beta1 ) and insulin-like growth factor-1 by osteoblasts in primary culture from trabecular bone of healthy post-menopausal women
Hashmi et al., Coron Artery Dis 2006
(Angina, Unstable) :
Role of interleukin-17 and
interleukin-17 induced cytokines
interleukin-6 and interleukin-8 in unstable coronary artery disease
Zhou et al., Nat Immunol 2007
:
We demonstrate here that
IL-6 induced expression of
IL-21 that amplified an autocrine loop to induce more IL-21 and IL-23 receptor in naive CD4 ( + ) T cells
Szabo et al., J Clin Immunol 1991
(Burns...) :
Furthermore,
interleukin-4 dependent downregulation of monocyte
interleukin-6 expression is confirmed at both the supernatant and the mRNA levels
Burch et al., Agents Actions 1991
(Wounds and Injuries) :
Basal interleukin-1 and 6 release were not affected by sucralfate, but the agent enhanced
interleukin-1 stimulated
interleukin-6 release from fibroblasts
Caprioli et al., J Immunol 2008
(Crohn Disease...) :
Consistently,
IL-21 is
inducible in T cells by
IL-6 , another cytokine that activates Stat3
Kattah et al., Arthritis Rheum 2008
:
IL-1beta and
IL-6 independently
induced IL-21 secretion, but the presence of IL-21 alone was not sufficient for IL-17 production
Krogh Rasmussen et al., Acta Endocrinol (Copenh) 1991
:
In conclusion, it is unlikely that
interleukin 6 by itself
mediates the biological effects of
interleukin 1 on human thyroid cells
Layh-Schmitt et al., Curr Opin Rheumatol 2008
(Spondylarthropathies) :
In mice, transforming growth factor-beta and
interleukin-6 are critical, whereas interleukin-23 is more important at later stages
promoting interleukin-17 production
Yamazaki et al., J Immunol 2008
(Encephalomyelitis, Autoimmune, Experimental) :
Th17 cells also express the CCR6 ligand CCL20, which is induced synergistically by TGF-beta and
IL-6 , which
requires STAT3, RORgamma and
IL-21
Huber et al., Proc Natl Acad Sci U S A 2008
:
Current dogma proposes that
IL-6 induces
IL-21 , which, in a STAT3 dependent manner, amplifies its own transcription, contributes to IL-17 production, and, moreover, promotes the expression of the IL-23 receptor
Dienz et al., J Exp Med 2009
:
We show that
IL-6 is sufficient and
necessary to induce
IL-21 production by naive and memory CD4 ( + ) T cells upon T cell receptor stimulation ...
IL-21 production by CD4 ( + ) T cells is
required for
IL-6 to promote B cell antibody production in vitro
Voo et al., Proc Natl Acad Sci U S A 2009
:
IL-17 producing CD4 ( + ) T helper ( Th17 ) cells have recently been defined as a unique subset of proinflammatory helper cells whose development depends on signaling
initiated by
IL-6 and TGF-beta, autocrine activity of
IL-21 , activation of STAT3, and induction of the orphan nuclear receptor RORgammat
Baigrie et al., Lymphokine Cytokine Res 1991
(Aortic Aneurysm...) :
A sequential interleukin-1 beta and interleukin-6 response has not been noted before in vivo, and would seem to provide evidence supporting the in vitro observation that
interleukin-1 induces
interleukin-6 synthesis and release
Braquet et al., Int Arch Allergy Appl Immunol 1991
:
We compared the
effects of platelet activating factor (PAF),
interleukin-1 beta (IL-1 beta) and polyriboinositic-polyribocytidylic acid ( poly-I:C ) on
IL-6 production by confluent L929 mouse fibroblasts
Li et al., J Immunol 2009
(Encephalomyelitis, Autoimmune, Experimental) :
It has been demonstrated previously that
IL-21 ,
induced by
IL-6 , stimulates the expression of the nuclear receptors retinoic acid related orphan receptor ( ROR ) gammat and RORalpha, which in turn induce expression of IL-17 ... We found that the impaired Th17 differentiation by E-FABP-deficient CD4 ( + ) T cells was associated with lower levels of
IL-21 expression in
response to
IL-6 , as well as reduced expression of RORgammat and RORalpha
Hale et al., PloS one 2009
(Disease Progression...) :
We report that robust changes in cytokine signal transduction occur during the progression of SLE in multiple immune cell subtypes including increased T cell responsiveness to IL-10 and ablation of Stat1 responses to IFNalpha, IFNgamma, IL-6, and
IL-21 , Stat3
responses to
IL-6 , Stat5 responses to IL-15, and Stat6 responses to IL-4
Hiramatsu et al., J Leukoc Biol 2010
:
Previous studies have shown that IL-6 potently
induces IL-21 production in CD4 ( + ) T cells, whereas TGF-beta inhibits
IL-6 induced IL-21 production in CD4 ( + ) T cells
Mus et al., Arthritis Rheum 2010
(Arthritis, Experimental) :
In contrast, transforming growth factor beta1 ( TGFbeta1 )
/IL-6 was a potent
inducer of RORgammat, RORalpha, IL-17A, IL-17F,
IL-21 , and FoxP3 in these cells
Zhang et al., Beijing Da Xue Xue Bao 2010
(Chlamydia Infections...) :
[ Early production of
interleukin-17 in airway upon Chlamydia trachomatis infection
increases the local secretion of
IL-6 and MIP-2 ]
Kim et al., Naunyn Schmiedebergs Arch Pharmacol 2011
:
Grape seed proanthocyanidin extract inhibits
interleukin-17 induced
interleukin-6 production via MAPK pathway in human pulmonary epithelial cells
Tanabe et al., Journal of neuroinflammation 2011
:
Midazolam suppresses
interleukin-1ß induced
interleukin-6 release from rat glial cells
Nakamura et al., Eur J Oral Sci 2011
(Gingivitis) :
Involvement of angiotensin II type 1 receptors in
interleukin-1ß induced
interleukin-6 production in human gingival fibroblasts
Zhang et al., Mol Cell Biol 1990
(Chromosome Deletion) :
Interleukin-6 induction by tumor necrosis factor and
interleukin-1 in human fibroblasts involves activation of a nuclear factor binding to a kappa B-like sequence
Nakayamada et al., Immunity 2011
:
Herein, we showed
interleukin-12 acting via the transcription factor STAT4
induced both
Il21 and Bcl6 genes, generating cells with features of both Tfh and Th1 cells
Diehl et al., Immunol Cell Biol 2012
:
IL-6 triggers
IL-21 production by human CD4+ T cells to drive STAT3 dependent plasma cell differentiation in B cells ... Here, we show that
IL-6 increased
IL-21 production by human CD4 ( + ) T cells, particularly in those that express the transcriptional regulator B cell lymphoma (BCL)6, which is required in mice for the development of C-X-C chemokine receptor type 5 ( CXCR5 ( + ) ) IL-21 producing T follicular helper ( T ( FH ) ) cells
Jin et al., J Autoimmun 2013
(Inflammation) :
IL-6 induces IL-21 production in CD4 T cells and IL-10 inducing effect of IL-6
requires both
IL-21 and IL-2
Libert et al., Eur J Immunol 1990
:
Induction of
interleukin 6 by human and murine recombinant
interleukin 1 in mice
Karrich et al., Blood 2013
:
Although
IL-21 did not
affect TLR induced type I IFNs,
IL-6 , and TNF-a nor expression of major-histocompatibility-complex class II or costimulatory molecules, IL-21 markedly increased expression of the serine protease granzyme B (GrB)
Carbone et al., International journal of biological sciences 2013
(Arthritis, Rheumatoid) :
Interleukin-6 receptor blockade selectively
reduces IL-21 production by CD4 T cells and IgG4 autoantibodies in rheumatoid arthritis
Kuroyanagi et al., Biochimie 2013
:
( - ) -Epigallocatechin gallate amplifies
interleukin-1 stimulated
interleukin-6 synthesis in osteoblast-like MC3T3-E1 cells
Bunning et al., Biochem Biophys Res Commun 1990
:
Independent
induction of
interleukin 6 and prostaglandin E2 by
interleukin 1 in human articular chondrocytes
Shalaby et al., Clin Immunol Immunopathol 1989
(Shock, Septic) :
Endotoxin, tumor necrosis factor-alpha and
interleukin 1
induce interleukin 6 production in vivo
Helle et al., Eur J Immunol 1988
:
Interleukin 6 is
involved in
interleukin 1-induced activities
Zimecki et al., Arch Immunol Ther Exp (Warsz) 1994
:
Interleukin 6 produced by activated thymocytes
induces interleukin 1 production by macrophages
Cadman et al., Neurosci Lett 1994
(Astrocytoma) :
cAMP is not involved in
interleukin-1 induced
interleukin-6 release from human astrocytoma cells
Carlson et al., J Neurochem 1995
(Astrocytoma) :
Prolonged exposure to phorbol ester eliminated subsequent stimulation by phorbol ester but only partially decreased
interleukin-1 induced
interleukin-6 and had no effect on the activities of selected inhibitors including calphostin C ... We conclude that tyrosine kinase activity is essential for
interleukin-1 induced
interleukin-6 production in U373 astrocytoma cells and that activity of a phorbol ester-insensitive, atypical protein kinase C isozyme may also be involved
Zitnik et al., Am J Physiol 1993
:
cAMP inhibition of
interleukin-1 induced
interleukin-6 production by human lung fibroblasts
Adams et al., Neurosurgery 1994
(Neuroma, Acoustic) :
Tumor necrosis factor-alpha,
interleukin-1-beta , and cholera toxin all
stimulated IL-6 secretion
Hoffmann et al., J Hepatol 1994
:
Furthermore, lipopolysaccharide, tumor necrosis factor-alpha, interferon-gamma,
interleukin-1 beta and phorbol ester
induced interleukin-6 production and, at the same time, suppressed the level of interleukin-6 receptor mRNA
Judd et al., Am J Physiol 1995
:
ZG cells released
IL-6 and TNF, and this release was
stimulated by lipopolysaccharide,
interleukin-1 alpha, interleukin-1 beta, a protein kinase C activator, and a calcium ionophore without affecting intracellular adenosine 3 ', 5'-cyclic monophosphate ( cAMP ) content
Ng et al., J Biol Chem 1994
:
Differential
induction of the
interleukin-6 gene by tumor necrosis factor and
interleukin-1
Moutabarrik et al., Scand J Immunol 1994
:
IL-6 was detected in the culture supernatants of human GEC and its production was
enhanced in time and dose dependent manner by lipopolysaccharide (LPS),
interleukin-1 beta (IL-1 beta) and tumour necrosis alpha ( TNF-alpha )
Ueo et al., J Am Coll Surg 1994
:
The
IL-6 secretion by skin explants was significantly
enhanced either by tumor necrosis factor or
interleukin-1 , while it was inhibited by corticosteroids
Utsunomiya et al., Eur J Pharmacol 1994
(Pleurisy) :
However, production of tumor necrosis factor (TNF) and
interleukin-1 in the pleural exudate was significantly
enhanced by the pretreatment with indomethacin, whereas the
interleukin-6 level was reduced
Levine et al., Psychoneuroendocrinology 1994
:
Pituitary-adrenal and
interleukin-6 responses to recombinant
interleukin-1 in neonatal rats
Boxman et al., J Invest Dermatol 1993
:
The remaining
interleukin-1 activity, however, was
sufficient for maximal induction of
interleukin-6 production in fibroblasts
de Fijter et al., Am J Kidney Dis 1996
:
In addition,
interleukin-1-beta induced
interleukin-6 production by human mesothelial cells was measured in the presence of concentrations of calcium increasing from 0 to 3.0 mmol/L. Fc receptor- mediated uptake of S epidermidis by PMO in the complete absence of Ca++ was comparable to that by PMO incubated in GHBSS with calcium
Topley et al., J Am Soc Nephrol 1996
:
Similarly,
interleukin (IL)-1 beta
induced IL-6 synthesis by HPMC was also only significantly reduced by the pH 5.2 lactate solution
Bodine et al., Endocrinology 1996
:
Finally,
interleukin-1 beta and tumor necrosis factor-alpha ( 1-1000 pM )
stimulated dose dependent increases in the secretion of
interleukin-6 and monocyte chemoattractant protein-1 at 34 C and 40C
Meyer et al., Clin Sci (Lond) 1997
(Endotoxemia...) :
3. Administration of endotoxin
induced a greater than fourfold increase in brain
interleukin-1 , a greater than threefold increase in
interleukin-6 and an increase in mRNA for both cytokines
Jones et al., J Pathol 1997
(Meningioma) :
Effect of
interleukin-1 and dexamethasone on
interleukin-6 production and growth in human meningiomas
Porro et al., J Pharmacol Exp Ther 1998
(Shock, Septic) :
In vitro experiments showed that ITF1779 inhibited not only huTNFalpha induced cytotoxicity on LM cells but also another response of the same cells,
interleukin-1 induced
interleukin-6 production
Kozawa et al., Prostaglandins Leukot Essent Fatty Acids 1998
:
However, retinoic acid had little effect on the
IL-6 synthesis
induced by
interleukin-1
Staels et al., Nature 1998
(Coronary Disease...) :
In these smooth-muscle cells, we find that PPARalpha ligands, and not PPARgamma ligands, inhibit
interleukin-1 induced production of
interleukin-6 and prostaglandin and expression of cyclooxygenase-2