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BCR — CSF2
Text-mined interactions from Literome
Li et al., Blood 2001
(Cell Transformation, Neoplastic...) :
Interleukin 3 and granulocyte-macrophage
colony stimulating factor are not
required for induction of chronic myeloid leukemia-like myeloproliferative disease in mice by
BCR/ABL
Perrotti et al., Nat Genet 2002
(Blast Crisis...) :
Here we show that expression of
BCR-ABL in myeloid precursor cells
leads to transcriptional suppression of the granulocyte colony stimulating factor receptor
G-CSF-R ( encoded by CSF3R ), possibly through down-modulation of C/EBPalpha-the principal regulator of granulocytic differentiation
Leis et al., Leukemia & lymphoma 2004
(Blast Crisis...) :
CSF levels were substantially below the concentration
required for inhibition of
BCR-ABL and killing of cell lines in vitro
Matsuguchi et al., J Biol Chem 1994
(Leukemia, Megakaryoblastic, Acute) :
Shc phosphorylation in myeloid cells is regulated by granulocyte macrophage
colony stimulating factor , interleukin-3, and steel factor and is constitutively
increased by
p210BCR/ABL
Zhang et al., Blood 1998
(Cell Transformation, Neoplastic...) :
Bcr-Abl efficiently
induces a myeloproliferative disease and production of excess interleukin-3 and granulocyte-macrophage
colony stimulating factor in mice : a novel model for chronic myelogenous leukemia