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SRC — SYK
Pathways - manually collected, often from reviews:
-
KEGG Tuberculosis:
Complex of CLEC7A-SRC
→
SYK
(protein-protein, activation)
-
NCI Pathway Database Class I PI3K signaling events:
Src family/SYK family/BLNK-LAT complex (FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-ZAP70_SYK-BLNK_LAT)
→
Src family/SYK family/BLNK-LAT/BTK-ITK complex (FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-ZAP70_SYK-BLNK_LAT-ITK_BTK)
(modification, collaborate)
Shan et al., J Biol Chem 1999, Baba et al., Proc Natl Acad Sci U S A 2001, Rawlings et al., Science 1996, August et al., Proc Natl Acad Sci U S A 1997
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database Class I PI3K signaling events:
Src family/SYK family/BLNK-LAT complex (FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-ZAP70_SYK-BLNK_LAT)
→
BTK-ITK (ITK/BTK)
(modification, collaborate)
Shan et al., J Biol Chem 1999, Baba et al., Proc Natl Acad Sci U S A 2001, Rawlings et al., Science 1996, August et al., Proc Natl Acad Sci U S A 1997
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database Class I PI3K signaling events:
Src family/SYK family/BLNK-LAT/BTK-ITK complex (FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-ZAP70_SYK-BLNK_LAT-ITK_BTK)
→
BTK-ITK (ITK/BTK)
(modification, collaborate)
Shan et al., J Biol Chem 1999, Baba et al., Proc Natl Acad Sci U S A 2001, Rawlings et al., Science 1996, August et al., Proc Natl Acad Sci U S A 1997
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database Class I PI3K signaling events:
None
→
Src family/SYK family/BLNK-LAT/BTK-ITK/PLC-gamma complex (FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-ZAP70_SYK-BLNK_LAT-ITK_BTK-PLCG1_PLCG2)
(modification, collaborate)
Rodriguez et al., Biochem J 2003
Evidence: mutant phenotype, other species
-
NCI Pathway Database Class I PI3K signaling events:
Src family/SYK family/BLNK-LAT/BTK-ITK/PLC-gamma complex (FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-ZAP70_SYK-BLNK_LAT-ITK_BTK-PLCG1_PLCG2)
(modification, activates)
Rodriguez et al., Biochem J 2003
Evidence: mutant phenotype, other species
-
NCI Pathway Database Class I PI3K signaling events:
Src family/SYK family/BLNK-LAT/BTK-ITK/PLC-gamma complex (FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-ZAP70_SYK-BLNK_LAT-ITK_BTK-PLCG1_PLCG2)
→
None
(modification, activates)
Rodriguez et al., Biochem J 2003
Evidence: mutant phenotype, other species
-
NCI Pathway Database Class I PI3K signaling events:
PLC-gamma family (PLCG1/PLCG2)
→
Src family/SYK family/BLNK-LAT/BTK-ITK/PLC-gamma complex (FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-ZAP70_SYK-BLNK_LAT-ITK_BTK-PLCG1_PLCG2)
(modification, collaborate)
Perez-Villar et al., J Immunol 1999, Rodriguez et al., Biochem J 2003, Serrano et al., J Immunol 2005
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database Class I PI3K signaling events:
PLC-gamma family (PLCG1/PLCG2)
→
Src family/SYK family/BLNK-LAT/BTK-ITK complex (FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-ZAP70_SYK-BLNK_LAT-ITK_BTK)
(modification, collaborate)
Perez-Villar et al., J Immunol 1999, Rodriguez et al., Biochem J 2003, Serrano et al., J Immunol 2005
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database Class I PI3K signaling events:
Src family/SYK family/BLNK-LAT/BTK-ITK/PLC-gamma complex (FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-ZAP70_SYK-BLNK_LAT-ITK_BTK-PLCG1_PLCG2)
→
Src family/SYK family/BLNK-LAT/BTK-ITK complex (FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-ZAP70_SYK-BLNK_LAT-ITK_BTK)
(modification, collaborate)
Perez-Villar et al., J Immunol 1999, Rodriguez et al., Biochem J 2003, Serrano et al., J Immunol 2005
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database FAS (CD95) signaling pathway:
FASLG/FAS (trimer)/Src/Syk complex (FAS-FASLG-SRC-SYK)
→
SYK (SYK)
(modification, collaborate)
Beier et al., J Neurosci 2005, Letellier et al., Immunity 2010
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database FAS (CD95) signaling pathway:
FASLG/FAS (trimer)/Src/Syk complex (FAS-FASLG-SRC-SYK)
→
Src (SRC)
(modification, collaborate)
Beier et al., J Neurosci 2005, Letellier et al., Immunity 2010
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database FAS (CD95) signaling pathway:
FASLG/FAS (trimer)/Src/Syk complex (FAS-FASLG-SRC-SYK)
→
FASLG/FAS (trimer) complex (FAS-FASLG)
(modification, collaborate)
Beier et al., J Neurosci 2005, Letellier et al., Immunity 2010
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database FAS (CD95) signaling pathway:
SYK (SYK)
→
Src (SRC)
(modification, collaborate)
Beier et al., J Neurosci 2005, Letellier et al., Immunity 2010
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database FAS (CD95) signaling pathway:
FASLG/FAS (trimer)/Src/Syk complex (FAS-FASLG-SRC-SYK)
→
PI3K Class IA family (PIK3CA/PIK3R1/PIK3CB/PIK3R1)
(modification, activates)
Beier et al., J Neurosci 2005, Letellier et al., Immunity 2010
-
Reactome Reaction:
SYK
→
SRC
(indirect_complex)
Kurosaki et al., J Exp Med 1994, Gao et al., EMBO J 1997
-
Reactome Reaction:
SYK
→
SRC
(reaction)
Kurosaki et al., J Exp Med 1994, Gao et al., EMBO J 1997
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
SRC
—
SYK
(physical association, affinity chromatography technology)
Asazuma et al., Blood 1997*
-
IRef Biogrid Interaction:
SRC
—
SYK
(direct interaction, enzymatic study)
Kurosaki et al., J Exp Med 1994
-
IRef Hprd Interaction:
SRC
—
SYK
(in vivo)
Kurosaki et al., J Exp Med 1994
-
IRef Intact Interaction:
Complex of 13 proteins
(association, anti bait coimmunoprecipitation)
Honda et al., Nat Immunol 2012
-
IRef Intact Interaction:
Complex of PTK2-SYK-MAL-SRC
(association, anti bait coimmunoprecipitation)
Honda et al., Nat Immunol 2012
-
IRef Ophid Interaction:
SRC
—
SYK
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
-
IRef Ophid Interaction:
SRC
—
SYK
(aggregation, confirmational text mining)
Kurosaki et al., J Exp Med 1994
Text-mined interactions from Literome
Pisegna et al., J Immunol 2002
:
Src dependent
Syk activation controls CD69 mediated signaling and function on human NK cells
Melander et al., Biochem J 2003
:
The following observations imply that Syk is such a kinase : ( i ) beta ( 2 ) integrins activated
Syk in a
Src dependent manner, ( ii ) Syk was associated with Cbl much longer than Fgr was, and ( iii ) the Syk inhibitor piceatannol ( 3,4,3',5'-tetrahydroxy- trans -stilbene ) abolished the Cbl associated kinase activity in an in vitro assay
Dangelmaier et al., Blood 2005
:
The
Src family kinase inhibitors
prevented Syk phosphorylation and its ubiquitination, indicating that the process is downstream of Src kinases
Leoncini et al., J Cell Biochem 2007
:
Likely oxidative stress could prime the non receptor mediated tyrosine kinase
p60src ,
inducing phosphorylation and activation of
p72syk
Lee et al., Arch Pharm Res 2007
:
In this study, we focused on investigating the
roles of
Syk in the regulation of
Src signaling in PDGF mediated vascular cell responses
Kahner et al., Platelets 2008
:
Further
Syk activation, as measured by tyrosine phosphorylation of Syk ( residues 525/526 ), in response to PAR activation was abolished in the
presence of
Src inhibitors
Kato et al., Platelets 2009
:
In vitro kinase assay with GST-Syk and -Aup1 proteins at the presence or absence of active Src, a potent activator of Syk, revealed that Aup1 does not directly influence
activation of
Syk by autophosphorylation or tyrosine phosphorylation by
Src
Chang et al., PloS one 2012
(MAP Kinase Signaling System) :
PKC can activate LKB1/AMPK, leading to phosphorylation and
activation of
Syk , and subsequent activation of
Src and FAK
Takata et al., FEBS Lett 1995
:
Kinase activity of
Src-PTK was
essential for tyrosine phosphorylation of
Syk and calcium mobilization upon receptor ligation, whereas these events were not affected by the mutation of SH2 domain