Gene interactions and pathways from curated databases and text-mining

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CDC42 — SRC

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Tu et al., J Biol Chem 2003 : The EGF dependent phosphorylation of Cdc42 occurs at tyrosine 64 in the Switch II domain and appears to be mediated through the Src tyrosine kinase, because both the expression of a dominant negative Src mutant ( mouse Src ( K297R ) ) and treatment of cells with the Src kinase inhibitor PP2 blocks the EGF stimulated phosphorylation of Cdc42 , whereas expression of an activated Src mutant ( Src ( Y529F ) ) promotes phosphorylation in the absence of EGF treatment ... The EGF stimulated activation of Cdc42 does require activated Src , as well as the Vav2 protein, a member of the Dbl family of guanine nucleotide exchange factors
Shimizu et al., J Biochem 2003 : Nectin furthermore induces activation of Cdc42 and Rac small G proteins through c-Src , which eventually regulates formation of the cadherin based adherens junctions through reorganization of the actin cytoskeleton, gene expression through activation of a mitogen activated protein kinase cascade, and cell polarization through cell polarity proteins
Fukuyama et al., J Biol Chem 2005 : Involvement of the c-Src-Crk-C3G-Rap1 signaling in the nectin induced activation of Cdc42 and formation of adherens junctions ... c-Src then activates Cdc42 through FRG, a Cdc42-GDP/GTP exchange factor ... These results indicate that Rap1 is activated by nectins through the c-Src-Crk-C3G signaling and involved in the nectin induced, c-Src- and FRG mediated activation of Cdc42 and formation of AJs
Sato et al., Cancer Sci 2005 : The activation of Cdc42 and Rac by the trans-interaction of nectin and nectin is mediated by c-Src , another small G protein, Rap1, a Cdc42-GEF, FRG, and a Rac-GEF, Vav2
Sakamoto et al., J Biol Chem 2006 : An immunoglobulin-like cell-cell adhesion molecule nectin first trans-interacts with each other to form cell-cell adhesion and induces activation of Rap1, Cdc42 , and Rac small G proteins through c-Src
Murata et al., J Neurosci 2006 : CD47 promotes neuronal development through Src- and FRG/Vav2 mediated activation of Rac and Cdc42 ... Inhibition of either FGD1 related Cdc42-guanine nucleotide exchange factor (GEF) ( FRG ) or Vav2, which is a GEF for Cdc42 and Rac and is activated by Src , also prevented the effects of CD47 on dendritic development ... These results indicate that CD47 promotes development of dendrites and axons in hippocampal neurons in a manner dependent, at least in part, on activation of Cdc42 and Rac mediated by Src as well as by FRG and Vav2
Shen et al., J Biol Chem 2008 : The role of Cdc42 in regulating E-cadherin ubiquitination and degradation is underscored by the fact that constitutively active Cdc42 ( F28L ) increases the activity of EGFR and Src and significantly enhances E-cadherin ubiquitination and lysosomal degradation
Jaffe et al., Int J Cancer 2008 (Colonic Neoplasms...) : The Src kinase inhibitor II (SrcKI-II) exerted a positive effect on RhoA activation, inhibited tyrosine phosphorylation of p190RhoGAP and inhibited leptin induced Cdc42 activation and leptin induced lamellopodium formation and cell invasion
Kant et al., Genes Dev 2011 (Inflammation) : This signaling pathway requires Src dependent activation of the guanosine nucleotide exchange factor Vav, activation of Rac/Cdc42 , and the engagement of the Rac/Cdc42 interaction site ( CRIB motif ) on mixed-lineage protein kinases ( MLKs )
Gomes et al., PloS one 2013 : The characterization of downstream molecular targets of c-Met activation, involved in the invasive phenotype, revealed increased phosphorylation of FAK and Src proteins and activation of Cdc42 , Rac1 and RhoA GTPases
Boschelli et al., Mol Cell Biol 1993 : These observations indicate that v-Src expression disrupts p34CDC28 kinase regulation, allowing DNA replication to proceed in the absence of a prior mitotic event