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BCL2 — EIF2AK2

Text-mined interactions from Literome

Ruvolo et al., J Biol Chem 2008 (Precursor Cell Lymphoblastic Leukemia-Lymphoma) : PKR regulates B56 ( alpha ) -mediated BCL2 phosphatase activity in acute lymphoblastic leukemia derived REH cells ... Suppression of PKR promoted BCL2 phosphorylation with concomitant loss of B56alpha phosphorylation at serine 28 and inhibition of mitochondrial PP2A activity
Yang et al., Cell Res 2009 : Repression of PKR mediates palmitate induced apoptosis in HepG2 cells through regulation of Bcl-2 ... The decrease in the phosphorylation of Bcl-2 at Ser70 upon exposure to palmitate is mediated by inhibition of PKR and possibly by c-Jun N-terminal kinase (JNK), whereas the phosphorylation of Bcl-2 at Ser87 is unaffected by palmitate or PKR
Cheng et al., Blood cancer journal 2013 : Thus, inhibition of PKR activity leads to hyperphosphorylation of Bcl-2 , stabilization of Bcl-2/Bax interaction and decreased Bax insertion into the outer mitochondrial membrane