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STAT2 — TYK2

Pathways - manually collected, often from reviews:

• BioCarta ifn alpha signaling pathway: IFN-alpha/IFNAR1/IFNAR2/JAK1/TYK2 complex (IFNAR2-JAK1-IFNAR1-IFNA1-TYK2) → STAT2 (modification, activates)
• KEGG Osteoclast differentiation: JAK1/TYK2 → STAT1/STAT2 (protein-protein, activation)
• KEGG Jak-STAT signaling pathway: JAK1/JAK2/JAK3/TYK2 → STAT1/STAT2/STAT3/STAT4/STAT5A/STAT5B/STAT6 (protein-protein, phosphorylation)
  
• KEGG Hepatitis C: JAK1/TYK2 → STAT1/STAT2 (protein-protein, activation)
• KEGG Measles: JAK1/TYK2 → STAT1/STAT2 (protein-protein, activation)
• KEGG Influenza A: JAK1/TYK2 → STAT1/STAT2 (protein-protein, activation)
• NCI Pathway Database IL27-mediated signaling events: STAT2 (STAT2) → IL27/IL27R/JAK2/TYK2 complex (IL27RA-JAK2-IL6ST-TYK2-IL27-EBI3) (modification, collaborate)
  
• Reactome Reaction: STAT2 → TYK2 (indirect_complex) You et al., Mol Cell Biol 1999, Rani et al., J Biol Chem 1999, Mowen et al., Mol Cell Biol 2000, Myers et al., J Biol Chem 2001, Lamken et al., J Mol Biol 2004, Cajean-Feroldi et al., Biochemistry 2004, Roisman et al., J Mol Biol 2005, Geiger et al., J Virol 2006, Uzé et al., Curr Top Microbiol Immunol 2007, Xu et al., Frontiers in bioscience : a journal and virtual library 2008, Colamonici et al., Mol Cell Biol 1994, Improta et al., Proc Natl Acad Sci U S A 1994, Müller et al., Nature 1993, Yan et al., EMBO J 1996, Gauzzi et al., J Biol Chem 1996, Jiao et al., Mol Cell Biol 1996, Domanski et al., J Biol Chem 1997
• Reactome Reaction: STAT2 → TYK2 (direct_complex)
• Reactome Reaction: STAT2 → TYK2 (reaction) Rani et al., J Biol Chem 1999, Mowen et al., Mol Cell Biol 2000, Lamken et al., J Mol Biol 2004, Cajean-Feroldi et al., Biochemistry 2004, Roisman et al., J Mol Biol 2005, Geiger et al., J Virol 2006, Wesoly et al., Acta biochimica Polonica 2007, Uzé et al., Curr Top Microbiol Immunol 2007, Colamonici et al., Mol Cell Biol 1994, Improta et al., Proc Natl Acad Sci U S A 1994, Müller et al., Nature 1993, Yan et al., EMBO J 1996, Li et al., J Biol Chem 1996, Gauzzi et al., J Biol Chem 1996, Domanski et al., J Biol Chem 1997

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: TYK2 — STAT2 (in vitro) Gupta et al., EMBO J 1996*
• IRef Hprd Interaction: TYK2 — STAT2 (in vivo) Gupta et al., EMBO J 1996*

Text-mined interactions from Literome

Lukashova et al., J Biol Chem 2001 : Activation of Tyk2 was followed by a time dependent 2-4-fold increase in the level of tyrosine phosphorylation of signal transducers and activators of transcription 1 ( STAT1 ), STAT2 , and STAT3 and a sustained 2.5-fold increase in STAT5 tyrosine phosphorylation
Geiger et al., J Virol 2006 : LMP-1 prevents Tyk2 phosphorylation and inhibits IFN-alpha stimulated STAT2 nuclear translocation and interferon stimulated response element transcriptional activity
Eilers et al., Cell Growth Differ 1996 : TYK2 activity led to an IFN-alpha independent appearance of tyrosine phosphorylated STAT1 but not STAT2 or JAK1 proteins