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SERPINB5 — TP53
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Zou et al., J Biol Chem 2000
(Breast Neoplasms...) :
p53 regulates the expression of the tumor suppressor gene
maspin ...
p53 activates the
maspin promoter by binding directly to the p53 consensus binding site present in the maspin promoter
Umekita et al., Int J Cancer 2002
(Breast Neoplasms) :
It has been reported that
maspin is expressed in normal human mammary epithelial cells but is downregulated during cancer progression, and that
p53 could
induce maspin expression by transcriptional activation
Song et al., Dig Dis Sci 2002
(Adenocarcinoma...) :
In conclusion, we demonstrated maspin expression in colon cancer with a sequential decreased expression rate from adenoma to metastatic carcinomas, which signifies the tumor suppressive function of maspin, and an inverse correlation with p53 and microvessel density, which indicates the regulatory
effect of
p53 on
maspin and anti-angiogenesis effect of maspin
Rose et al., Gynecol Oncol 2006
(Ovarian Neoplasms) :
In the maspin negative ovarian cancer cell line A222,
maspin could be
induced following 5-aza-dC treatment or by forced overexpression of
p53
Webber et al., Applied immunohistochemistry & molecular morphology : AIMM / official publication of the Society for Applied Immunohistochemistry 2008
(Melanoma...) :
The inverse relationship between maspin and p53 expression predicted by hypothesized
p53 regulation of
maspin transcription, or any other correlation between these 2 markers, is not demonstrated in MM cases, using either classic individual slide ( P=0.20 ) or TMA ( P=0.85 ) methods when cutoffs for both markers are set at 10 % or greater of cells staining
Eitel et al., Cell cycle (Georgetown, Tex.) 2009
(Glioblastoma) :
PTEN and
p53 are
required for hypoxia induced expression of
maspin in glioblastoma cells ... In response to genotoxic stress,
p53 induces the tumor suppressors
maspin and PTEN ... Altering the expression of PTEN and/or
p53 attenuated
maspin gene induction under hypoxic conditions