Llorente-Cortés et al., J Mol Biol 2006
:
Our results demonstrate that LDL stimulates LRP1 transcription and decreases SREBP-2 active form which negatively regulates LRP1 transcription
Cal et al., Journal of translational medicine 2012
(Myocardial Ischemia) :
Thus, the purpose of this study was to assess the effect of hypercholesterolemic LDL and hypertrigliceridemic VLDL dose on LRP1 expression in cardiomyocytes, as well as the potential correlation between LRP1 expression and neutral lipid accumulation in the left ventricle tissue from ischemic cardiomyopathy patients
Costales et al., Atherosclerosis 2013
:
Native ( nLDL ) or aggregated LDL ( agLDL ) per se downregulated SREBP-2 expression levels and increased LRP1 expression
Wu et al., Arch Biochem Biophys 1996
:
LDL can also completely inhibit the binding of alpha 2M* to purified LRP