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BCL2 — SOD1
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Huang et al., Diabetes Res Clin Pract 2007
(Diabetes Mellitus, Experimental) :
Diabetic rats showed elevated MDA level and CAT activity, but lower activities of
SOD and GSH-Px. Carvedilol treatment
increased activities of antioxidant enzymes and expression of
Bcl-2 in healthy rats as well as diabetic rats
Gatta et al., Neurosci Lett 2009
(Alzheimer Disease...) :
Interestingly, exposure to H ( 2 ) O ( 2 )
induced a significant decrease of
Bcl-2 mRNA transcript, while
Sod1 and Bax mRNAs levels were unchanged in PBMCs derived from MCI and AD patients
Pedrini et al., Hum Mol Genet 2010
(Amyotrophic Lateral Sclerosis) :
In cells, mouse and human spinal cord with SOD1 mutations, the binding to mutant
SOD1 triggers a conformational change in
Bcl-2 that results in the uncovering of its toxic BH3 domain and conversion of Bcl-2 into a toxic protein
Chen et al., J Cell Mol Med 2011
(Choline Deficiency...) :
The DSS induced colitis was dramatically more severe in the D DSS ( + ) group compared with each other group, with no change in
superoxide dismutase and glutathione peroxidase activity, but decreased expression of caspase-3 and Bax, and
increased Bcl-2 levels
Han et al., Zhong Yao Cai 2011
(Atherosclerosis...) :
Compared with the model group, DHZCP significantly reduced serum MDA level and MPO activity in the vascular wall, increased serum NO level and
SOD activity, and
inhibited PCNA and
BCL-2 expressions in the vascular wall