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FOS — ILK

Text-mined interactions from Literome

Troussard et al., Mol Cell Biol 1999 : The formation of this complex is inhibited by cotransfection with active GSK-3 or kinase-deficient ILK, suggesting that ILK may regulate AP-1 activation by inhibiting GSK-3, which has previously been shown to be a negative regulator of AP-1
Troussard et al., Oncogene 2000 (Glioblastoma) : Furthermore, both MMP-9 promoter and AP-1 activities were inhibited by the ILK inhibitor
Sawai et al., Oncogene 2006 (Disease Progression...) : In this study, we demonstrated that ILK and beta ( 1 ) -integrin play important roles in interleukin (IL)-1alpha induced enhancement of adhesion and invasion of pancreatic cancer cells through p38 mitogen activated protein kinase ( MAPK ) signaling pathway and activator protein-1 (AP-1) activation ... Overexpressed ILK enhances the IL-1alpha induced p38 MAPK phosphorylation more strongly through glycogen synthase kinase 3 ( GSK-3 ) activation, and subsequently induces AP-1 activation, which promotes aggressive capabilities of pancreatic cancer cells
Mi et al., Carcinogenesis 2006 (Mammary Neoplasms, Animal...) : Our results indicate that binding of an RGD bearing ligand, such as OPN, to integrin receptors in metastatic 4T1 cells transcriptionally mediates MMP-2, uPA and OPN expression through ILK dependent AP-1 activity and significantly increases in vitro functional correlates of metastasis
Tan et al., J Cell Physiol 2012 : Moreover, CCN3 induced c-Jun translocation into the nucleus, and the binding of c-Jun to the AP-1 element on the BMP-4 promoter were both inhibited by specific inhibitors of the ILK , p38, and JNK cascades