Ulmann et al., J Neurosci 2008
(Neuralgia...) :
Up-regulation of P2X4 receptors in spinal microglia after peripheral nerve injury mediates BDNF release and neuropathic pain ... Using in vitro and in vivo models, we provide direct evidence that P2X(4)R stimulation leads to the release of BDNF from activated microglia and, most likely phosphorylation of the NR1 subunit of NMDA receptors in dorsal horn neurons of the spinal cord
Trang et al., J Neurosci 2009
:
It is known that P2X4 purinoceptors (P2X4Rs) cause the release of brain derived neurotrophic factor (BDNF) from microglia, which is necessary for maintaining pain hypersensitivity after nerve injury ... However, there is a critical gap in understanding how activation of microglial P2X4Rs leads to the release of BDNF Klein et al., PloS one 2012
(Arthritis, Rheumatoid...) :
ATP induced brain derived neurotrophic factor expression and release from osteoarthritis synovial fibroblasts is mediated by purinergic receptor P2X4