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AKT1 — RHOB

Text-mined interactions from Literome

Liu et al., FEBS Lett 2000 : Geranylgeranylated RhoB is sufficient to mediate tissue-specific suppression of Akt kinase activity by farnesyltransferase inhibitors
Jiang et al., Mol Cell Biol 2004 (Cell Transformation, Neoplastic...) : Akt mediates Ras downregulation of RhoB , a suppressor of transformation, invasion, and metastasis
Canguilhem et al., J Biol Chem 2005 : Inhibition of UVB induced EGFR activation prevents RhoB protein expression and AKT phosphorylation but not the early activation of RhoB
Delord et al., Br J Cancer 2010 (Disease Models, Animal...) : Trastuzumab induced in vivo tissue remodelling associated in vitro with inhibition of the active forms of AKT and PTEN and RhoB induction in an ovarian carcinoma model
Kazerounian et al., Cancer Res 2013 (Breast Neoplasms...) : Here, we show in established murine and human models of breast cancer how differential regulation of Akt by the small GTPase RhoB in cancer cells or stromal endothelial cells determines their dormancy versus outgrowth when angiogenesis becomes critical