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ERBB2 — NRG4

Pathways - manually collected, often from reviews:

• NCI Pathway Database ErbB receptor signaling network: ErbB4/ErbB2/neuregulin 4 complex (ERBB4-ERBB2-NRG4) → ErbB4 (ERBB4) (modification, collaborate) Harari et al., Oncogene 1999*, Hayes et al., Oncogene 2008*
  Evidence: assay, physical interaction
• NCI Pathway Database ErbB receptor signaling network: ErbB4/ErbB2/neuregulin 4 complex (ERBB4-ERBB2-NRG4) → ErbB2 (ERBB2) (modification, collaborate) Harari et al., Oncogene 1999*, Hayes et al., Oncogene 2008*
  Evidence: assay, physical interaction
• NCI Pathway Database ErbB receptor signaling network: ErbB4/ErbB2/neuregulin 4 complex (ERBB4-ERBB2-NRG4) → neuregulin 4 (NRG4) (modification, collaborate) Harari et al., Oncogene 1999*, Hayes et al., Oncogene 2008*
  Evidence: assay, physical interaction
• NCI Pathway Database ErbB receptor signaling network: ErbB2 (ERBB2) → neuregulin 4 (NRG4) (modification, collaborate) Harari et al., Oncogene 1999*, Hayes et al., Oncogene 2008*
  Evidence: assay, physical interaction
• Reactome Reaction: ERBB2 → NRG4 (reaction) Borg et al., Nat Cell Biol 2000, Xu et al., J Biol Chem 2001, Vijapurkar et al., Exp Cell Res 2003, Citri et al., EMBO Rep 2004, Xu et al., Nature structural & molecular biology 2005, Walton et al., J Biol Chem 1990, Li et al., Cell Signal 2007, Xu et al., Mol Cell Biol 2007, Hazan et al., Cell Growth Differ 1990, Kaushansky et al., Chem Biol 2008, Wada et al., Cell 1990, Helin et al., J Biol Chem 1991, Margolis et al., J Biol Chem 1989, Ricci et al., Oncogene 1995, Wallasch et al., EMBO J 1995, Prigent et al., EMBO J 1994, Soler et al., Oncogene 1994, Segatto et al., Oncogene 1993, Karunagaran et al., EMBO J 1996, Cohen et al., J Biol Chem 1996, Pinkas-Kramarski et al., EMBO J 1996
• Reactome Reaction: ERBB2 → NRG4 (indirect_complex)

Text-mined interactions from Literome

Tal-Or et al., Prostate 2003 (Prostatic Neoplasms) : Our results demonstrate that NRG activates ErbB-2/ErbB-3 heterodimers and induces cell death of LNCaP cells
Yuste et al., Cancer Res 2005 (Breast Neoplasms) : Activation of ErbB2 by overexpression or by transmembrane neuregulin results in differential signaling and sensitivity to herceptin
Wehr et al., Nat Methods 2006 : In a first biological application, we monitored neuregulin induced ErbB2/ErbB4 receptor tyrosine kinase heterodimerization
Monje et al., J Biol Chem 2008 : Protein kinase A-mediated gating of neuregulin dependent ErbB2-ErbB3 activation underlies the synergistic action of cAMP on Schwann cell proliferation ... Two basic observations defined the synergistic action of PKA as `` gating '' for neuregulin-ErbB signaling : 1 ) the activation of PKA was not sufficient to induce S-phase entry or the activation of either ErbB2 or ErbB3 ; and 2 ) the presence of neuregulin was strictly required to ignite ErbB activation and thereby ERK and Akt signaling ... However, PKA directly phosphorylated ErbB2 on Thr-686, a highly conserved intracellular regulatory site that was required for the PKA mediated synergistic enhancement of neuregulin induced ErbB2-ErbB3 activation and proliferation in SCs ... The gating action of PKA on neuregulin induced ErbB2-ErbB3 activation has important biological significance, because it insures signal amplification into the ERK and Akt pathways without compromising either the neuregulin dependence or the high specificity of ErbB signaling pathways
Schmukler et al., PloS one 2012 (MAP Kinase Signaling System...) : Previously, it was demonstrated that NRG activates ErbB-2/ErbB-3 heterodimers to induce LNCaP cell death, whereas, EGF activates ErbB-1/ErbB-1 or ErbB-1/ErbB-2 dimers to induce cell growth and survival