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NFKBIA — SPP1

Text-mined interactions from Literome

Khan et al., J Cell Biochem 2002 : OPN also caused an increase in Bcl-X ( L ) mRNA levels, suppressed the apparent dispersion of Bcl-X ( L ) throughout the cytoplasm, and slightly enhanced IkappaB-alpha protein degradation
Philip et al., J Biol Chem 2003 : However, curcumin a known anti-inflammatory and anticarcinogenic agent suppressed OPN induced I kappa B alpha phosphorylation and degradation by inhibiting the IKK activity ... To our knowledge, this is the first report that OPN induces NF kappa B activity through phosphorylation and degradation of I kappa B alpha by activating IKK that ultimately triggers the activation of pro-MMP-2 and further demonstrates that curcumin potently suppresses OPN induced cell migration, tumor growth, and NF kappa B-mediated pro-MMP-2 activation by blocking the IKK/I kappa B alpha signaling pathways
Das et al., J Biol Chem 2003 (Breast Neoplasms) : OPN enhances the interaction between IkappaBalpha kinase (IKK) and phosphorylated Akt ... OPN also induces NFkappaB activation through phosphorylation and degradation of IkappaBalpha by inducing the IKK activity
Rangaswami et al., J Biol Chem 2004 (MAP Kinase Signaling System...) : Nuclear factor inducing kinase plays a crucial role in osteopontin induced MAPK/IkappaBalpha kinase dependent nuclear factor kappaB mediated promatrix metalloproteinase-9 activation
Rangaswami et al., J Biol Chem 2005 (Neoplasm Invasiveness) : We have recently demonstrated that nuclear factor inducing kinase ( NIK ) plays a crucial role in osteopontin (OPN) induced mitogen activated protein kinase/I kappa B alpha kinase dependent nuclear factor kappa B (NF kappa B)-mediated promatrix metalloproteinase-9 activation ( Rangaswami, H., Bulbule, A., and Kundu, G. C. ( 2004 ) J. Biol. Chem. 279, 38921-38935 )
Das et al., IUBMB Life 2005 (Disease Progression...) : OPN enhances the interaction between IkappaBalpha kinase (IKK) and phosphorylated Akt ... OPN also induces NFkappaB activation through phosphorylation and degradation of IkappaBalpha by inducing the IKK activity
Rice et al., J Vasc Res 2006 : Overexpression of a dominant negative ( DN ) IKKbeta protein prevents IkappaBalpha phosphorylation, NF-kappaB activation, and inhibits the protective effects of OPN ... Finally, functional inhibition of integrin beta3 dependent NF-kappaB signaling decreases OPN induced IkappaBalpha , IKKbeta and NIK phosphorylation
Fong et al., Lung Cancer 2009 (Adenocarcinoma...) : Stimulation of A549 cells with OPN also induced IkappaB kinase alpha/beta ( IKK alpha/beta ) phosphorylation, IkappaBalpha phosphorylation, p65 Ser ( 536 ) phosphorylation, and kappaB-luciferase activity