◀ Back to NFKBIA

CNTN2 — NFKBIA

Text-mined interactions from Literome

Jin et al., J Biol Chem 1999 : This direct interaction with IKK-gamma correlates with Tax induced IkappaB-alpha phosphorylation and NF-kappaB activation
Maggirwar et al., Oncogene 1995 : Activation of NF-kappa B/Rel by Tax involves degradation of I kappa B alpha and is blocked by a proteasome inhibitor ... Together, these studies suggest that Tax activation of NF-kappa B/Rel may involve induction of phosphorylation and subsequent proteasome mediated degradation of the inhibitor I kappa B alpha
Suzuki et al., Oncogene 1995 : We herein report the effects of Tax on I kappa B-alpha , another member of I kappa B family proteins expressed in human T cells
Kanno et al., J Biol Chem 1995 (Leukemia-Lymphoma, Adult T-Cell) : Degradation of I kappa B-alpha is enhanced by Tax , resulting in the liberation of some NF-kappa B, which then translocates into the nucleus ... Here we have investigated the mechanism by which Tax causes degradation of I kappa B-alpha ... These results suggest that Tax triggers I kappa B-alpha degradation and thus NF-kappa B activation by a mechanism that converges with that induced by extracellular stimulation such as phorbol 12-myristate 13-acetate/ionomycin or tumor necrosis factor alpha
Kanno et al., Mol Cell Biol 1994 : We demonstrate for the first time a Tax induced proteolytic degradation of the NF-kappa B inhibitor, I kappa B-alpha , which may trigger the initial nuclear translocation of NF-kappa B
Pepin et al., Virology 1994 : These studies demonstrate : ( 1 ) distinct compartmentalization of NF-kappa B precursors and products, ( 2 ) differential induction of the endogenous I kappa B alpha protein by transfected NF-kappa B subunits, ( 3 ) subcellular relocalization of Tax to the cytoplasm or nucleus depending on the coexpressed NF-kappa B subunit, and ( 4 ) Tax interaction with the Rel homology domain region of NFKB2
Muñoz et al., J Virol 1994 : Tax induces nuclear translocation of NF-kappa B through dissociation of cytoplasmic complexes containing p105 or p100 but does not induce degradation of I kappa B alpha/MAD3
McKinsey et al., Mol Cell Biol 1996 : In this report, we provide evidence that in addition to acting on IkappaBalpha , Tax stimulates the turnover Of IkappaBbeta via a related targeting mechanism ... Despite the dual specificity of HTLV-1 Tax for IkappaBalpha and IkappaBbeta at the protein level, Tax selectively stimulates NF-kappaB directed transcription of the IkappaBalpha gene
Lindholm et al., J Virol 1996 : Tax1 did not directly increase PKC phosphorylation of I kappa B alpha
Yin et al., Cell 1998 : Thus, Tax mediated increases in NF-kappaB nuclear translocation result from direct interactions of Tax and MEKK1 leading to enhanced IKKbeta phosphorylation of IkappaB alpha
Chu et al., J Biol Chem 1998 (HTLV-I Infections) : Tax induced breakdown of IkappaBalpha requires phosphorylation of the inhibitor at Ser-32 and Ser-36, which is also a prerequisite for the transient activation of NF-kappaB in cytokine treated T lymphocytes
Geleziunas et al., Mol Cell Biol 1998 (Cell Transformation, Viral...) : Tax expression promotes N-terminal phosphorylation and degradation of IkappaB alpha , a principal cytoplasmic inhibitor of NF-kappaB
Coscoy et al., Virology 1998 (Cell Transformation, Neoplastic...) : In tumor derived cells, the expression of Tax led to an increased degradation of IkappaB alpha and IkappaB beta and caused stable nuclear translocation of nuclear factor-kappaB
Petropoulos et al., Virology 1998 : Tax also enhanced binding of I kappa B alpha to the proteasome subunit HsN3, resulting in a Tax enhanced, constitutive degradation of wild-type and mutated forms of I kappa B alpha in the absence of phosphorylation and ubiquitination ... The association of Tax with hypophosphorylated I kappa B alpha may prevent I kappa B alpha from binding to NF-kappa B and also target I kappa B alpha to the proteasome for degradation via a phosphorylation independent pathway