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NFKB1 — TAB2
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Takaesu et al., Mol Cell 2000
:
Expression of
TAB2 induces JNK and
NF-kappaB activation, whereas a dominant negative mutant TAB2 impairs their activation by IL-1
Mizukami et al., Mol Cell Biol 2002
(MAP Kinase Signaling System) :
Dominant negative forms of TAK1 and
TAB2 inhibit
NF-kappaB activation induced by overexpression of RANK ... Furthermore, in murine monocyte RAW 264.7 cells, dominant negative forms of TAK1 and
TAB2 inhibit
NF-kappaB activation induced by RANKL and endogenous TAK1 is activated in response to RANKL stimulation
Ishitani et al., EMBO J 2003
(Inflammation) :
TAB2 , a TAK1 binding protein, is
involved in IL-1 induced
NF-kappaB activation by physically linking TAK1 to TRAF6
Mashima et al., J Biol Chem 2005
:
Furthermore, we demonstrated that
NF-kappaB activation
induced by TRAF6 and
TAB2 was impaired by co-expression of FLN29, suggesting FLN29 may regulate the downstream of TRAF6
Morlon et al., Hum Mol Genet 2005
(Ectodermal Dysplasia) :
TAB2 , TRAF6 and TAK1 are
involved in
NF-kappaB activation induced by the TNF-receptor, Edar and its adaptator Edaradd ... Moreover, we show that dominant negative forms of
TAB2 , TRAF6 and TAK1
blocked the
NF-kappaB activation induced by Edaradd
Zhuang et al., Cell Signal 2006
:
Drosophila
TAB2 is
required for the immune activation of JNK and
NF-kappaB
Tian et al., J Biol Chem 2007
:
RBCK1 negatively
regulates tumor necrosis factor- and interleukin-1 triggered
NF-kappaB activation by targeting
TAB2/3 for degradation
Suzuki et al., J Biol Chem 2007
(Cell Transformation, Viral...) :
Constitutive activation of TAK1 by HTLV-1 tax dependent overexpression of
TAB2 induces activation of JNK-ATF2 but not
IKK-NF-kappaB
Yu et al., Biochem Biophys Res Commun 2008
:
We found that
TAB2 physically interacts with Tax and
augments Tax induced
NF-kappaB activity
Tareen et al., Virology 2011
:
We show that human Trim5a also affects levels of TAB2, resulting in abrogation of
TAB2 dependent
NF-kappaB activation