Gudi et al., J Environ Pathol Toxicol Oncol 2009
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Siva-1 promotes K-48 polyubiquitination of TRAF2 and inhibits TCR mediated activation of NF-kappaB ... Previously, we showed that Siva-1 inhibited the activity of the prosurvival transcription factor NF-kappaB ... The above results demonstrated an important role for endogenous Siva-1 in negatively regulating NF-kappaB activation by targeting TRAF2
Resch et al., J Cell Sci 2009
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Reporter-gene analysis revealed that Siva1 inhibits XIAP- and TAK1-TAB1 mediated NFkappaB activation ... Our findings suggest that, via physical interaction with XIAP and TAK1, Siva1 diminishes NFkappaB and enhances JNK activity to favour apoptosis