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NFKB1 — PCBD1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Bubici et al., Histol Histopathol 2006
(MAP Kinase Signaling System) :
With regard to TNFalpha, the
NF-kappaB mediated inhibition of
PCD seems to involve an attenuation of the c-Jun-N-terminal kinase (JNK) cascade mediated through the induction of select downstream targets such as the caspase inhibitor XIAP, the zinc-finger protein A20, and the inhibitor of the MKK7/JNKK2 kinase, Gadd45beta/Myd118
Dutta et al., Oncogene 2006
(Cell Transformation, Viral...) :
However, improper
regulation of
PCD by
NF-kappaB can have severe pathologic consequences, ranging from neurodegeneration to cancer, where its activity often precludes effective therapy
Pham et al., Mol Cell Biol 2007
(Neoplasms) :
The mechanism by which
NF-kappaB inhibits
PCD triggered by chemotherapeutic drugs, however, remains poorly understood
Kuntzen et al., Methods Mol Biol 2007
(Cell Transformation, Neoplastic) :
Activation of
NF-KB inhibits
programmed cell death (PCD) triggered by tumor necrosis factor alpha (TNFalpha) and several other stimuli
Fan et al., Adv Exp Med Biol 2008
(Neoplasms) :
NF-kappaB most commonly antagonizes PCD by activating the expression of antiapoptotic proteins and antioxidant molecules, but it can also
promote PCD under certain conditions and in certain cell types ... Here, we review the
role of
NF-kappaB in apoptotic and necrotic
PCD , the mechanisms involved, and how its activity in the cell death response impacts cancer development, progression, and therapy