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CXCL12 — NFKB1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Cherla et al., J Immunol 2001
:
In this study, we have explored the
roles of the second messenger NO and the transcription factor
NF-kappa B in
SDF1 alpha induced T cell migration ... Furthermore, we observed that inhibitors of the transcription factor
NF-kappa B , which is linked to NO signaling pathways, also significantly
blocked the
SDF1 alpha induced chemotactic response
Han et al., J Clin Invest 2001
:
TNF-alpha mediates
SDF-1 alpha
induced NF-kappa B activation and cytotoxic effects in primary astrocytes ... TNF-alpha treatment mimicked
SDF-1 alpha
induction of
NF-kappa B , IL-1 alpha/beta, and RANTES, as well as cell death ; neutralizing antibodies against TNF-alpha opposed these responses
Méndez-Samperio et al., J Interferon Cytokine Res 2002
:
Finally, two specific
NF-kappa B inhibitors, sulfasalazine and caffeic acid phenetyl ester ( CAPE ), strongly
inhibited the production of
CXCL-8 by human monocytes infected with M. bovis
Chandrasekar et al., J Biol Chem 2004
(Arteriosclerosis...) :
In conclusion,
CXCL16 is a potent and direct
activator of
NF-kappaB and induces kappa B-dependent proinflammatory gene transcription
Si et al., J Immunol 2004
(Acquired Immunodeficiency Syndrome) :
Interestingly, although LPS induced
IL-8/CXCL8 was
dependent on
NF-kappaB , the baseline or 15d-PGJ ( 2 ) -mediated IL-8/CXCL8 production was NF-kappaB independent
Cinatl et al., Int J Mol Med 2005
(Colonic Neoplasms...) :
High hydrocortisone concentrations ( > or =50 microg/ml ) completely prevented increased DNA binding activity of AP-1 and
NF-kappaB and
inhibited up-regulation of
CXCL8 and CXCL10, but did not reduce chemokine expression to basal levels
Keshamouni et al., Neoplasia (New York, N.Y.) 2005
(Carcinoma, Non-Small-Cell Lung...) :
Similarly, an inhibitor of
NF-kappa B activation ( PDTC ) also
blocked CXCL8 , CXCL5, and CXCL1 production, consistent with their NF-kappa B-dependent regulation
Kukreja et al., Cancer Res 2005
(Bone Neoplasms...) :
We tested the hypothesis that enhanced expression of CXCR4 in prostate cancer cells is dependent upon
SDF-1alpha mediated activation of
nuclear factor-kappaB (NF-kappaB) ... PD98059 cotreatment significantly inhibited
SDF-1alpha induced
NF-kappaB reporter activity and CXCR4 receptor expression as shown by flow cytometry
Maroni et al., Carcinogenesis 2007
(Breast Neoplasms...) :
HGF
induces CXCR4 and
CXCL12 mediated tumor invasion through Ets1 and
NF-kappaB
Amin et al., Arthritis Rheum 2007
(Arthritis, Rheumatoid) :
IL-18 induced
SDF-1alpha/CXCL12 up-regulation was
dependent on JNK, p38 MAPK, phosphatidylinositol 3-kinase (PI3K), and
NFkappaB
Tang et al., Carcinogenesis 2008
(Lung Neoplasms...) :
Both mitogen activated protein kinase kinase inhibitor and ERK mutant also antagonized
SDF-1alpha induced
NF-kappaB-driven luciferase promoter activity
D'Aversa et al., J Neurosci Res 2008
(AIDS Dementia Complex...) :
Gel shift analyses demonstrated that
NFkappaB and AP-1, but not C/EBPbeta,
mediate microglial
CXCL8 production
Yang et al., Mol Immunol 2008
(Escherichia coli Infections...) :
Bovine TLR2 and TLR4 properly transduce signals from Staphylococcus aureus and E. coli, but S. aureus fails to both activate
NF-kappaB in mammary epithelial cells and to quickly
induce TNFalpha and interleukin-8 (
CXCL8 ) expression in the udder
Bischoff et al., J Cell Biochem 2008
:
NF-kappaB inhibition
resulted in a decrease in
CXCL8 levels in hMSCs grown in non-OGM
Rehman et al., J Biol Chem 2008
(Carcinoma, Squamous Cell...) :
In this report we show that the NF-kappaB signaling pathway is activated in response to SDF-1alpha in HNSCC while primary and immortalized keratinocytes show no
SDF-1alpha mediated
NF-kappaB activity ... We found that
SDF-1alpha mediated
NF-kappaB signaling is independent of phosphoinositide 3-kinase/Akt and ERK/MAPK pathways ... We observed that
SDF-1alpha induces IkappaBalpha phosphorylation and degradation and the nuclear translocation of
NF-kappaB in HNSCC cell lines, suggesting that SDF-1alpha activates the classical NF-kappaB signaling pathway ... Contrary to previous reports,
SDF-1alpha induced
NF-kappaB activation is not mediated by tumor necrosis factor alpha
Martin et al., J Biol Chem 2009
:
Furthermore, we identified the components of the CBM complex, Carma3, Bcl10, and Malt1, as key mediators of the
CXCL8/IL8 induced
NFkappaB activation and VEGF up-regulation
Ho et al., J Immunol 2009
:
In contrast, NE did not induce NRF expression in A549 and Beas-2B cells, where NE only stimulates
NF-kappaB activation and
IL-8/CXCL8 induction
Khalaf et al., BMC immunology 2010
(Inflammation) :
The present study shows that
NF-kappaB regulated IL-6 but not
CXCL8
Madge et al., J Biol Chem 2010
:
Classical
NF-kappaB activation negatively
regulates noncanonical NF-kappaB dependent
CXCL12 expression