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STAT6 — TNF

Text-mined interactions from Literome

Levings et al., J Immunol 1999 : These data show that STAT6 is required for the IL-4 mediated inhibition of the production of TNF-alpha and IL-12 stimulated by LPS alone, but that IL-4 also activates distinct, STAT6 independent mechanism(s) that inhibit the IFN-gamma mediated enhancement of IL-12 and TNF-alpha production
Hoeck et al., J Immunol 2001 : TNF-alpha activated gene expression at the transcriptional level in a STAT6 dependent manner, because : 1 ) eotaxin-1 promoter luciferase constructs were TNF-alpha inducible in STAT6-defective HEK293 cells only on cotransfection of STAT6 expression vector, an effect that was partially mediated by activation induced binding of NF-kappa B proteins to a composite STAT6/NF-kappa B element ; 2 ) reporter constructs defective in STAT6 DNA binding did not respond to TNF-alpha stimulation ; 3 ) eotaxin-1 protein secretion was detected only in STAT6 transfected HEK293 cell supernatants on TNF-alpha treatment ; and 4 ) a trans-dominant negative STAT6 protein inhibited TNF-alpha induced eotaxin-1 secretion in primary fibroblasts ... TNF-alpha inducibility of the IL-8 and monocyte chemoattractant protein-1 genes was not dependent on STAT6 expression in the same experimental systems
Bonder et al., Cytokine 2002 : Like MDMac, interferon alpha ( IFNalpha ) -treated monocytes expressed less IL-4 receptor gamma c chain, reduced levels of IL-4 activated STAT6 and IL-4 could not suppress LPS induced TNFalpha production
Zamorano et al., J Immunol 2003 : We previously found that IL-4 and TNF-alpha cooperate in the activation of STAT6 and NF-kappaB, suggesting that these transcription factors are regulated by common intracellular signaling pathways
Suzuki et al., J Exp Med 2003 : IL-4-Stat6 signaling induces tristetraprolin expression and inhibits TNF-alpha production in mast cells ... IL-4-Stat6 signaling induced TNF-alpha mRNA destabilization in an AU-rich element ( ARE ) -dependent manner, but did not affect TNF-alpha promoter activity
Sato et al., Biochem Biophys Res Commun 2004 : Western blotting analysis demonstrated that IFN-gamma downmodulated STAT6 phosphorylation induced by IL-4 and TNF-alpha
Liu et al., J Immunol 2007 : Activation of NF-kappaB, STAT6 , and STAT1 was induced in eosinophils by TNF-alpha , IL-4, and IFN-gamma, respectively