◀ Back to PTX3
FGF2 — PTX3
Pathways - manually collected, often from reviews:
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OpenBEL Selventa BEL large corpus:
FGF2
→
Complex of FGF2-PTX3
(directlyDecreases)
Evidence: PTX3 binds FGF2, but not FGF1 and FGF4, with high affinity [166]. In endothelial cells, PTX3 prevents the binding of FGF2 to cell surface FGFRs and HSPGs, with a consequent inhibition of cell proliferation and migration, and inhibits FGF2-dependent neovascularization in the CAM assay.
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WikiPathways Lung fibrosis:
PTX3
→
FGF2
(unknown)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Bobola et al., Development 2003
:
Mesenchymal patterning by Hoxa2 requires blocking
Fgf dependent
activation of
Ptx1
Camozzi et al., J Biol Chem 2006
(Neovascularization, Pathologic) :
Accordingly, purified recombinant PTX3- ( 1-178 ) binds FGF2, prevents PTX3/FGF2 interaction, and inhibits FGF2 mitogenic activity in ECs ... Consistently, the synthetic peptides PTX3- ( 82-110 ) and PTX3- ( 97-110 ) bind
FGF2 and
inhibit the interaction of FGF2 with
PTX3 immobilized to a BIAcore sensor chip, FGF2 dependent EC proliferation, and angiogenesis in vivo
Zhang et al., PloS one 2012
(Asthma) :
Moreover,
PTX3 induced CCL11/eotaxin-1 release whilst inhibited the
fibroblast growth factor-2 (FGF-2)-driven HASMC chemotactic activity ... Moreover,
PTX3 induced CCL11/eotaxin-1 release whilst inhibited the fibroblast growth factor-2
(FGF-2)-driven HASMC chemotactic activity