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IRF6 — PTGES

Text-mined interactions from Literome

Ban et al., Planta Med 2003 : It also inhibited the LPS induced expressions of cyclooxygenase (COX)-2 and microsomal prostaglandin E synthase ( mPGES )
Zhang et al., J Neuroimmunol 2006 : Cyclooxygenase (COX)-2 and membrane bound prostaglandin E synthase-1 ( mPGES-1 ) were induced by treatment with lipopolysaccharide (LPS) but not with PS liposomes
Bezugla et al., Prostaglandins Other Lipid Mediat 2006 : LPS induces an increase of COX-2 and mPGES-1 , but does not change COX-1, cPGES, mPGES-2 and TxAS at protein level ... Dexamethasone suppresses almost completely the LPS induced effects on COX-2 and mPGES-1
Degousee et al., J Biol Chem 2006 (Inflammation) : In neonatal cardiomyocytes, interleukin-1beta and lipopolysaccharide (LPS) both stimulated mPGES-1 mRNA expression and increased mPGES-1 mRNA stability and protein synthesis but failed to increase mPGES-1 mRNA transcription ... Treatment with the JNK1/2 inhibitor, SP600125, abrogated the increases in mPGES-1 mRNA stability, mPGES-1 protein synthesis, and PGE ( 2 ) release induced by interleukin-1beta or LPS ... In contrast, infection of jnk1 ( -/- ) cardiomyocytes with an adenovirus encoding phosphorylation-resistant JNK2 ( ad-JNK2-DN ), or of jnk2 ( -/- ) cardiomyocytes with ad-JNK1-DN, significantly decreased LPS stimulated mPGES-1 protein synthesis ... Similarly, co-infection with ad-JNK1-DN and ad-JNK2-DN attenuated LPS stimulated mPGES-1 protein synthesis in cardiomyocytes from wild type mice
Ninomiya et al., J Steroid Biochem Mol Biol 2007 : Here, we examined the effects of liver X receptor ( LXR ) ligands on LPS induced mPGES-1 expression in murine peritoneal macrophages
Mosca et al., J Leukoc Biol 2007 : Alternatively activated M2 monocytes-macrophages exposed to IL-4, IL-13, or IL-10 did not express mPGES-1, whereas in these cells, IL-4, IL-13, and to a lesser extent, IL-10 or IFN-gamma inhibited LPS induced , mPGES-1 expression
de Oliveira et al., Glia 2008 : The LPS induced increase of mPGES-1 was inhibited by different signaling pathway inhibitors, such as SP600125, LY294002, GF109203X, and SC-514, suggesting the involvement of c-Jun N-terminal kinase (JNK), phosphatidylinositol 3-kinase (PI-3K)/Akt, protein kinase C ( PKC ) pathways, and the nuclear factor (NF)-kappaB, respectively ... In contrast to other reports, LPS induced mPGES-1 synthesis was not invariably coupled to the synthesis of COX-2, since inhibition of PI-3K with LY294002 decreased mPGES-1 but increased COX-2 levels
Li et al., J Neurosci Res 2010 (Encephalitis...) : BV-2 cells also exhibited COX-2 and mPGES-1 expression which was enhanced by LPS
Kunze et al., Prostaglandins Other Lipid Mediat 2010 (Inflammation) : IL1beta, TNF-alpha and LPS enhanced the expression of COX-2 and mPGES1 whereas phorbol ester enhanced COX-2 expression only
Díaz-Muñoz et al., Cell Signal 2010 : LPS stimulation induced the coordinated synthesis of COX-2 and mPGES-1 that resulted in an enhanced production of PGE ( 2 ) in RAW 264.7 macrophages ... Inhibition of Egr-1 expression reduced substantially LPS mediated induction of COX-2 and mPGES-1 expression, resulting in a decrease in PGE ( 2 ) production
Brenneis et al., J Biol Chem 2011 (Disease Models, Animal...) : Interestingly, we found that activation of E-prostanoid ( EP ) 2 and EP4 receptors, but not EP1, EP3, PGI(2) receptor ( IP ), thromboxane A(2) receptor ( TP ), PGD(2) receptor ( DP ), and PGF ( 2 ) receptor ( FP ), efficiently blocked LPS induced tumor necrosis factor a (TNFa) synthesis and COX-2 and mPGES-1 induction as well as prostaglandin synthesis in spinal cultures
Shoeb et al., Free Radic Biol Med 2011 (Inflammation) : LPS induced activation of redox-sensitive signaling intermediates such as MAPKs, transcription factor NF-?B, and EGR-1, a transcriptional regulator of mPGES-1 , which in collaboration with COX-2 leads to the production of PGE2, was also significantly prevented by AR inhibition
Mamidi et al., Immunobiology 2012 (Sarcoidosis, Pulmonary) : We also observed that LPS acts synergistically with ATRA in MDMs and strongly induces PTGES expression