Gene interactions and pathways from curated databases and text-mining

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STAT1 — STAT5A

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Yu et al., J Immunol 1999 : Moreover, the STAT element was shown to bind STAT5a/b induced by IL-2 as well as STAT1alpha induced by IL-6 in human NK cells
Yamashita et al., J Biol Chem 1999 (Lymphoma, T-Cell) : Short term incubation ( < 60 min ) of prolactin-responsive Nb2 lymphoma cells at high density selectively blocked prolactin stimulation of p42/p44 mitogen activated protein kinases and transcription factors Stat1 and Stat3 but not prolactin activation of Stat5 or the tyrosine kinase Jak2
Rebsamen et al., J Mol Cell Cardiol 2000 (Cardiomegaly) : EGF did not activate Stat1 and Stat3, but did induce a rapid and transient activation of Stat5 , which corresponded mainly to Stat5b DNA binding
Vidal et al., Eur J Immunol 2001 : Furthermore, STAT1 activation but weak or no activation of STAT3 or STAT5 respectively, could be detected in MB-stimulated MDM. Using MonoMac6 cells, we observed high C/EBPbeta and AP-1 but weaker and transient NF-kappaB activation by MB.Moreover, the truncated form of C/EBPbeta, known to repress HIV-1 transcription, was detected in extracts from MB-treated THP-1 cells
Xue et al., Int Immunol 2002 : Serine phosphorylation has also been found to occur in a number of STAT proteins, including Stat1, Sat3, Stat4, Stat5a, Stat5b and Stat6, and was shown to be important for maximal transcriptional activation mediated by Stat1 , Stat3 and Stat4, but not for Stat5a or Stat5b
Wellbrock et al., Curr Biol 2005 (Melanoma) : The overexpressed STAT5 diminished IFNalpha triggered STAT1 activation, most evidently through upregulation of the inhibitor of cytokine signaling CIS
Huang et al., J Clin Invest 2007 (Inflammation...) : Enforced expression of STAT1 , IRF-1, or GATA-1 enhanced phosphorylation of STAT1, STAT3, and STAT5 in cultured Gata1-deficient murine megakaryocytes, with concomitant megakaryocyte maturation
Wang et al., Cell cycle (Georgetown, Tex.) 2009 : Site-specific Stat1 phosphorylation also controls the transcriptional activities of Stat3 and Stat5 and is capable of orchestrating a complex regulatory network that influences the expression of genes involved in cell cycle control, cell-cell adhesion and signal transduction
Barclay et al., Endocrinology 2011 (Fatty Liver) : Because loss of STAT5 signaling results in elevated STAT1 and STAT3 activity and intracellular lipid accumulation, we have used DN-STAT5a/b, DN-STAT1, constitutively active ( CA ) -STAT3, or addition of oleate/palmitate in the hepatoma line to assign which of these apply to individual targets in STAT5 signaling deficiency
Nishiyama-Fujita et al., Leuk Res 2013 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : Suppression of TC-PTP induced activation of STAT5 , leading to imatinib resistance, while prolonged phosphorylation of STAT1 was induced by IFN-a, triggering cell death in KT-1 cells
Yu et al., J Immunol 1996 : IL-2 induced less STAT1 alpha activation and IFN-alpha induced greater STAT5 activation in NK3.3 cells compared with preactivated primary NK cells