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CA2 — PIP
Text-mined interactions from Literome
Chen et al., Biochemistry 1999
:
The mFc gamma RIIb2 cytoplasmic peptide does not bind, in the
presence or absence of
Ca2+ , to PS/PC,
PIP2/PC , or PC vesicles
Ohizumi et al., Can J Physiol Pharmacol 1999
:
PIP2 caused a concentration dependent increase in
Ca2+ release from SR of chemically skinned fibers from skeletal muscle
Tucker et al., J Cell Biol 2003
:
These data suggest that syts trigger fusion via their
Ca2+ regulated interactions with t-SNAREs and
PIP2 , target molecules known to play critical roles in exocytosis
Rebecchi et al., Biochemistry 1992
:
The binding strength increased further ( Ka congruent to 10 ( 6 ) M-1 ) when the vesicles also contained 30 % PS. High-affinity binding of PLC-delta to
PIP2 did not
require Ca2+
Huang et al., J Biol Chem 1991
:
The
PIP2 bound PKC could further interact with phosphatidylserine in the
presence of
Ca2+ to form a larger complex ... Binding of PKC to both
PIP2 and phosphatidylserine in the
presence of
Ca2+ was also evident by changes in the intrinsic fluorescence of PKC
Vasudevan et al., J Cell Sci 2009
(Calcium Signaling) :
In summary,
PIP5K-I gamma positively
regulates antigen stimulated
Ca2+ release from ER stores, whereas PIP5K-I beta negatively regulates store operated Ca2+ entry, suggesting that these different PIP5K-I isoforms synthesize functionally distinct pools of PtdIns ( 4,5 ) P2 at the plasma membrane
Kobayashi et al., Biochem Biophys Res Commun 1989
:
PIP2 enhanced the caffeine induced Ca2+ release from SR vesicles at low concentrations and
triggered Ca2+ release by itself at high concentrations
Schwertz et al., Arch Biochem Biophys 1989
:
In the
presence of
Ca2+ , addition of Mg2+, La3+, or Sr2+ ( 10 ( -3 ) M ) inhibited
PIP2-PLC while Mn2+ and Gd3+ stimulated activity
Strosznajder et al., Neurochem Res 1989
:
In the presence of EGTA PIP2 was actively degraded, opposite to PI and
PIP which
require Ca2+ for their hydrolysis
Giraud et al., Biochim Biophys Acta 1988
:
PMA treatment had no effect on the
Ca2+ dependent
PIP/PIP2 phospholipase C activity measured in isolated membranes
Mack et al., Biochem Cell Biol 1988
:
A low
Ca2+ dependent
PIP2 phosphatase activity, not present in other tissues, was also detected ...
Ca2+ dependent
PIP2 phosphatase activity is not correlated with the activity or subcellular distribution of any of the other hydrolases and seems to be a separate enzyme
Quist et al., Arch Biochem Biophys 1985
:
MgCl2 inhibited the rate of
Ca2+ stimulated breakdown of
PIP and PIP2 at Ca2+ concentrations less than 10 microM, but did not have any appreciable effects at higher Ca2+ concentrations
Sasaguri et al., Biochem J 1985
:
The addition of 1 mM-MgCl2 to the assay medium markedly inhibited the activity of
PIP2 PDE in both fractions in the
presence of free
Ca2+ ( 10 ( -8 ) -10 ( -5 ) M )
Magnaldo et al., FEBS Lett 1987
:
A
Ca2+ dependent
PIP2 and PIP phospholipase C activity was characterized by measuring the rate of formation of inositol tris- and bisphosphate
Nakamura et al., Endocrinology 1987
:
After the release induced by a maximal amount of IP3,
PIP2 could
induce a further
Ca2+ release
Banerjee et al., Hum Reprod 1995
:
The
SABP also
induces an increase in intracellular
Ca2+ in spermatozoa, as seen by FURA-2 AM studies
Kardasz et al., Eur J Endocrinol 1997
:
There was no
effect of 10 ( -6 ) mol/l
Ca2+ on the levels of
PIP and PIP2
Lin et al., J Biol Chem 1997
:
We present evidence that
PIP2 binding to the gelsolin family of capping proteins is
enhanced by
Ca2+