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IL8 — NA

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Gosset et al., Eur Respir J 1999 : Since exogenous as well as endogenous thiols could be potent inhibitors of the production of cytokines, the effects of N-acetylcysteine (NAC) , glutathione ( GSH ) and modulated GSH synthesis on the production of tumour necrosis factor (TNF)-alpha, interleukin (IL)-6 and IL-8 by human alveolar macrophages ( AMs ) was evaluated, as well as the potential role of intracellular GSH depletion on the effect of exogenous thiols ... Similarly, NAC inhibited the production of TNF-alpha, IL-6 and IL-8 in GSH depleted AMs obtained by BSO pretreatment
Hashimoto et al., Am J Respir Crit Care Med 2000 : NAC inhibited DEP induced p38 MAP kinase activation and IL-8 and RANTES production
Hashimoto et al., Br J Pharmacol 2001 : However, the effect of N-acetylcysteine (NAC) , which acts as a precursor of glutathione ( GSH ) synthesis, on TNF-alpha induced activation of p38 MAP kinase pathway and p38 MAP kinase mediated IL-8 production by human pulmonary vascular endothelial cells has not been determined ... To clarify these issues, we examined the effect of NAC on TNF-alpha induced activation of p38 MAP kinase, MAP kinase kinase (MKK) 3 and MKK6 which are upstream regulators of p38 MAP kinase, and p38 MAP kinase mediated IL-8 production
Gon et al., Respirology 2000 (Respiratory Distress Syndrome, Adult) : In the present study, we showed that BLM induced the expression of IL-8 protein and mRNA in BEAS-2B cells, and N-acetyl-L-cysteine (NAC) inhibited IL-8 expression
Wu et al., Am J Respir Cell Mol Biol 2002 (MAP Kinase Signaling System) : In addition, activations of the IL-8 gene and AP-1 by MG132 and lactacystin were inhibited by GSH and NAC
Chu et al., Dig Dis Sci 2003 (Helicobacter Infections...) : The present study aims to investigate whether H. pylori induced IL-8 expression is regulated by NF-kappaB and AP-1 in gastric epithelial AGS cells and whether this transcriptional regulation of IL-8 is inhibited by N-acetylcysteine (NAC) ... NAC inhibited H. pylori induced activation of transcription factors and IL-8 expression in AGS cells
Jafari et al., Respirology 2004 (Respiratory Distress Syndrome, Adult) : NAC blocked stretch induced NF-kappa B and AP-1 binding and inhibited IL-8 mRNA expression
Hwang et al., Oncogene 2004 (Stomach Neoplasms) : N-acetyl cysteine (NAC) prevented the IL-1beta induced ROS production and IL-8 expression
Sawai et al., Med Sci Monit 2005 (Pancreatic Neoplasms) : Exogenous H2O2 enhanced IL-8 secretion and N-acetyl cysteine (NAC) prevented IL-1alpha induced ROS production and IL-8 secretion
Radomska-Leśniewska et al., J Physiol Pharmacol 2006 : NAC inhibited the TNF-alpha/IL-1 beta stimulated ICAM-1 expression and IL-8 release from both cell lines in a concentration dependent manner
Vassallo et al., Mol Immunol 2008 (Inflammation) : The generation of interleukin-8 ( CXCL8/IL-8 ) by human DCs conditioned with CSE was suppressed by the anti-oxidant n-acetyl cysteine (NAC) , implying the involvement of oxidant sensitive pathways as a primary mechanism involved in the enhanced CXCL8/IL-8 generation
Jiang et al., Sichuan Da Xue Xue Bao Yi Xue Ban 2008 : To investigate the effects of N-acetylcysteine ( NAC ) on the expression of IL-8 and the activity of NF-kappaB, which are induced by lipopolysaccharide (LPS) in human uterine smooth cell ... ( 1 ) NAC significantly inhibited IL-8 mRNA expression and production in human uterine smooth cells with a concentration dependent way ( 5-15 mmol/L )
Radomska-Leśniewska et al., Pharmacol Rep 2010 (Lung Diseases, Interstitial...) : Therefore, the aim of the present work was to evaluate the effect of NAC on interleukin-8 (IL-8) and matrix metalloproteinase-9 (MMP-9) production as well as intercellular cell adhesion molecule-1 ( ICAM-1 ) expression by BAL cells from interstitial lung diseases
Abdel Baki et al., PloS one 2010 (Brain Injuries) : When dosed 3 hours before injury, MINO plus NAC as single drugs had no effect on interleukin-1 formation ; together they synergistically lowered interleukin-1 levels
Xiong et al., Aesthetic Plast Surg 2012 : The reported research aimed to identify the effects of N-acetyl-L-cysteine (NAC) on the proliferation, death, and IL-8 production of ADSCs
Ehsani et al., Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences 2012 : To evaluate the role of prophylactic ibuprofen and N-acetylcysteine (NAC) on the levels of tumor necrosis factor alpha ( TNF- a ), interleukin- 6(IL-6) and IL-17 and post-treatment pain level in chronic periapical lesions
Zhang et al., J Int Med Res 2013 (Inflammation...) : NAC attenuated silica induced increases in TNF-a, IL-8 and hsCRP in BALF and serum
Horiguchi et al., Lymphokine Cytokine Res 1993 : This notion was also supported by our findings that a superoxide generating agent, paraquat, induced IL-8 production in human PBMC and that NAC blocked this paraquat induced IL-8 production
Muñoz et al., Blood 1996 : Both PDTC and NAC inhibited , in a dose dependent manner, the synthesis of IL-6, IL-8 , and GM-CSF induced by tumor necrosis factor (TNF)-alpha or bacterial lipopolysaccharides (LPS) in human umbilical vein endothelial cells ( HUVEC )
Tanaka et al., Biochem Biophys Res Commun 1997 (Astrocytoma) : Transient expression analysis using the chloramphenicol acetyltransferase assay revealed that activation of the IL-8 promoter by LPS was stimulated by BSO and was suppressed by NAC ; likewise LPS induced activation of both NF kappa B and AP-1 was enhanced by BSO and inhibited by NAC
Matsumoto et al., Respir Med 1998 : However, the effect of NAC on the secretion of interleukin-8-(IL-8) , which is an important mediator of the pathogenesis of acute lung injury through the recruitment of neutrophils, has not been determined ... In the present study, therefore, we examined the effect of NAC on IL-8 secretion by IL-1 alpha stimulated bronchial epithelial cells ... NAC inhibited IL-8 secretion by bronchial epithelial cells in a dose dependent manner