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AKT3 — RAF1
Text-mined interactions from Literome
Tong et al., American journal of physiology. Renal physiology 2004
:
Aldosterone stimulated PI3-K signaling impinged on the MAPK1/2 cascade at the level of
Akt mediated phosphorylation of
c-Raf at an established negative regulatory site
Taniguchi et al., Mol Reprod Dev 2004
(MAP Kinase Signaling System) :
Here, we showed that HGF activated the distinct phosphorylation of
Raf-1 , MEK1/2, and ERK1/2, but did not
induce phosphorylation of
Akt
Hahn et al., Mol Cancer Ther 2005
(Leukemia) :
These events were associated with marked down-regulation of
Raf-1 , MEK, and ERK phosphorylation, diminished
Akt activation , and enhanced phosphorylation of c-Jun NH2-terminal kinase (JNK)
Carpentier et al., Rev Neurol (Paris) 2005
(Brain Neoplasms...) :
High expression of the EGF receptor by tumor cells,
activation of the
PI3K/Akt and the
Ras/Raf pathways represent interesting targets for new selective drugs under development
Lee et al., Am J Physiol Heart Circ Physiol 2006
(Inflammation...) :
However, inhibitors of
Raf-1 and MEK or a dominant negative ERK mutant
blocked FKN induced ERK, but not
Akt and eNOS, phosphorylation
Romano et al., Endocrinology 2006
:
Under the same conditions, PI3K and
Akt inhibition also both
increased Raf-1 kinase activity and the levels of GTP bound ( active form ) monomeric G protein Rap1, which suggests that a down-regulation of the ERK-1/2 cascade is induced by the PI3K/Akt signaling pathway in unstimulated cells
Le Guilloux et al., Rev Neurol (Paris) 2008
(Brain Neoplasms...) :
High expression of the EGF receptor by tumor cells,
activation of the
PI3K/Akt and the
Ras/Raf pathways represent interesting targets for new selective drugs under development
Han et al., Cell Signal 2009
(Lymphoma) :
Akt negatively
regulates Raf-1 activation ( Ser259 ), partially explaining the difference between resistant and intermediate cells
Ozel et al., Cell communication and signaling : CCS 2012
:
Analysis of RAF-1 S259 phosphorylation, being a major mediator of the negative
regulation of
RAF-1 by
AKT , showed decreased pRAF-1 S259 levels in LY294002 treated M13MDA435-1 hybrid cells