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GAPDH — MAOB

Text-mined interactions from Literome

Ou et al., Neurotox Res 2009 : However, their mechanism of action is not clear, since the neuroprotective effect of MAO B inhibitors is associated with the blockage of glyceraldehyde-3-phosphate dehydrogenase ( GAPDH ) -death cascade, rather than the inhibition of MAO B ... Over-expression of GAPDH in cells enhances ethanol induced cell death, and also increases the ethanol induced activation of MAO B ... In contrast, the MAO B inhibitors rasagiline and selegiline ( 0.25 nM ) and the rasagiline metabolite, 1-R-aminoindan ( 1 muM ) decreases the ethanol induced MAO B, prevents nuclear translocation of GAPDH and reduces cell death ... Furthermore, silencing TIEG2 using RNAi significantly reduces GAPDH induced MAO B upregulation and neurotoxicity
Ou et al., Biol Psychiatry 2010 (Alcoholism...) : Nuclear GAPDH interacts with the transcriptional activator, transforming growth factor-beta-inducible early gene 2 ( TIEG2 ), and augments TIEG2 mediated MAO B transactivation, which results in cell damage in neuronal cells exposed to EtOH ... Ethanol elicited nuclear GAPDH augments TIEG2 mediated MAO B , which might play a role in brain damage in subjects with alcoholism