Gene interactions and pathways from curated databases and text-mining

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RELA — TRAF6

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Puls et al., J Cell Sci 1999 (Inflammation) : Using LMP1 mutants, we show that activation of Cdc42 and JNK/NF(kappa)B occur through distinct pathways and that Cdc42 activation is independent of LMP1 's interaction with TRADD and TRAF proteins
Irie et al., FEBS Lett 1999 : The results revealed that TRAF6 mediated NF-kappaB activation was suppressed by p75 ( NTR ) and that the p75 ( NTR ) -mediated NF-kappaB suppression was reduced by FAP-1 expression
Carpentier et al., FEBS Lett 1999 : Interestingly, overexpression of TRAF1 in HEK293T completely prevented NF-kappaB activation induced by TNF, IL-1, or overexpression of TRAF2 or TRAF6
Pomerantz et al., EMBO J 1999 : However, TANK also displays the ability to stimulate TRAF mediated NF-kappaB activation ... The TBK1-TANK-TRAF2 signaling complex functions upstream of NIK and the IKK complex and represents an alternative to the receptor signaling complex for TRAF mediated activation of NF-kappaB
Jalukar et al., J Immunol 2000 : Interestingly, however, although we could show TRAF6 dependent CD40 mediated activation of NF-kappaB in 293 kidney epithelial cells, no such effect was seen in B cells, suggesting that TRAF6 has cell-type-specific functions
Sanz et al., EMBO J 2000 : Here we demonstrate that the inhibition of the aPKCs or the down-regulation of p62 severely abrogates NF-kappaB activation by IL-1 and TRAF6 , suggesting that both proteins are critical intermediaries in this pathway
Nomura et al., Genes Cells 2000 : NF-kappaB activation by IKK-i is significantly blocked by coexpression of the N-terminal domain of I-TRAF , dominant negative TRAF2, and dominant negative NIK and IKK-beta
Zapata et al., J Biol Chem 2000 : In contrast, TRAF2 mediated NFkappaB induction was partially inhibited by DTRAF1 ... Mutants of DTRAF1 lacking the N-terminal region inhibited NFkappaB induction by either TRAF2 or TRAF6
Takaori-Kondo et al., Biochem Biophys Res Commun 2000 : TRAF3 blocked OX40-, TRAF2 induced NF-kappaB activation, but not NIK- and IKKalpha induced NF-kappaB activation , indicating that TRAF3 blocks the pathway between TRAF2 and NIK
Shu et al., Proc Natl Acad Sci U S A 2000 : Moreover, BCMA mediated NF-kappaB activation is inhibited by dominant negative mutants of TNF receptor associated factor 5 (TRAF5), TRAF6 , NF-kappaB inducing kinase (NIK), and IkappaB kinase (IKK)
Mochida et al., Kokubyo Gakkai Zasshi 2000 (MAP Kinase Signaling System) : Here we report that ASK 1 binds to TAK 1 and dissociates TAK 1 from TNF receptor associated factor 6 ( TRAF 6 ), and inhibits TAK 1- and TRAF 6- , but not NF-kappa B-inducing kinase (NIK) induced NF-kappa B activation
Brady et al., Biochem J 2000 : The overexpression of TRAF-6 or NIK was sufficient to activate NF-kappaB and the Cepsilon promoter, whereas their dominant negative counterparts decreased the ability of CD40 to activate NF-kappaB and the Cepsilon promoter
Deng et al., Cell 2000 : Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin conjugating enzyme complex and a unique polyubiquitin chain
Takeuchi et al., Antioxid Redox Signal 2000 : Our data show that TRX treatment inhibits NF-kappaB dependent transcription at the level of downstream of TRAFs and upstream of NIK : TRX inhibited TRAF2-, TRAF5-, and TRAF6 induced NF-kappaB activation but does not inhibit NIK-, IKKalpha-, and MEKK induced activation
Zapata et al., J Biol Chem 2001 : Analysis of various MUL and USP7 mutants by transient transfection assays indicated that the TDs of these proteins are necessary and sufficient for suppressing NF-kappaB induction by TRAF2 and TRAF6 as well as certain TRAF binding TNF family receptors
Funakoshi et al., Int Immunopharmacol 2001 : These observations were prominent particularly in the TRAF6 transfection system, in which overexpression of wild type TRAF6 augmented the IL-1 mediated NF-kappa B and AP-1 activation, while dominant negative TRAF6 construct ( delta TRAF6 ) suppressed these activation ... Namely, LY294002 inhibited TRAF6 mediated IL-1 induced NF-kappa B and AP-1 activation markedly, while SB203580 inhibited TRAF6 induced AP-1 activation but not NF-kappa B activation
Chandel et al., J Biol Chem 2001 : Consistent with its anti-apoptotic function, Bcl-x ( L ) interfered with TRAF mediated ROS generation but not NF-kappaB activation
Schultheiss et al., EMBO J 2001 (Cell Transformation, Viral...) : In addition, NF-kappaB but not c-Jun N-terminal kinase 1 ( JNK1 ) induction by LMP1 involves TRAF6
Wooten et al., Mol Cell Biol 2001 : The functional relevance of these mutations was tested by determining the ability of each mutant to support TRAF6 activation of NF-kappaB , with significant impairment by the Y325F PKC-iota mutant
Shin et al., J Biol Chem 2002 : A novel human C ( 2 ) H ( 2 ) -type zinc finger family protein was identified, which when coexpressed with TRAF6 led to a suppression of TRAF6 induced activation of NF-kappa B and c-Jun N-terminal kinase
Naito et al., Proc Natl Acad Sci U S A 2002 (Ectodermal Dysplasia) : Furthermore, TRAF6 is essential for the XEDAR mediated NFkappaB activation
Wu et al., Gene Expr 2002 : In addition, ZAS3 associates with a TNF receptor associated factor to inhibit NF-kappaB- and JNK/ SAPK mediated signaling of TNF-alpha
Lee et al., J Biochem Mol Biol 2002 : The inhibitory effect of the TAK1 mutant on RANK- and TRAF induced NF-kappaB activation was also observed, but less efficiently
Kanamori et al., FEBS Lett 2002 : Act1 mediated NF-kappaB activation was inhibited by a dominant negative mutant of TRAF6 in a dose dependent manner, and IL-1 induced NF-kappaB activation was inhibited by a high level of Act1 expression
Yeo et al., J Biol Chem 2003 : In contrast, overexpression of DN-IRAK1 or DN-TRAF6 only partially inhibited CpG DNA induced Cox-2 promoter activity and NF-kappaB activation, indicating the presence of additional signaling modulators downstream of MyD88
Henkler et al., J Biol Chem 2003 : The role of tumor necrosis factor (TNF) receptor associated factor ( TRAF)-1 in NF-kappaB activation by various members of the TNF receptor family is not well understood, and conflicting data have been published
Pollet et al., Blood 2003 : Bacterial lipopolysaccharide directly induces angiogenesis through TRAF6 mediated activation of NF-kappaB and c-Jun N-terminal kinase
Bin et al., J Biol Chem 2003 : Moreover, TIRP mediated NF-kappaB activation is inhibited by dominant negative mutants of IRAK, IRAK-2, TRAF6 , and IKKbeta
Lee et al., J Biol Chem 2003 : Saturated fatty acid ( lauric acid ) -induced NFkappaB activation was inhibited by a dominant negative mutant of TLR4, MyD88, IRAK-1, TRAF6 , or IkappaBalpha in macrophages ( RAW264.7 ) and 293T cells transfected with TLR4 and MD2
Sakon et al., EMBO J 2003 : Importantly, TNF does not induce ROS accumulation or prolonged MAPK activation in wild-type MEFs, indicating that TRAF mediated NF-kappaB activation normally suppresses the TNF induced ROS accumulation that subsequently induces prolonged MAPK activation and necrotic cell death
Trompouki et al., Nature 2003 : The inhibition of NF-kappaB activation by CYLD is mediated , at least in part, by the deubiquitination and inactivation of TNFR associated factor 2 (TRAF2) and, to a lesser extent, TRAF6
Sugatani et al., J Cell Biochem 2003 : RANKL stimulation of RANK/TRAF6 signaling increases nuclear factor-kappaB (NFkappaB) nuclear translocation and activates the Akt/PKB cell survival pathway
Fotin-Mleczek et al., J Biol Chem 2004 : Accordingly, TRAF1 inhibited CD40 dependent but not TNF-R1 dependent NF-kappaB activation
Takada et al., J Biol Chem 2004 : NF-kappaB reporter activity induced by TNF receptor 1, TNF receptor associated death domain, TNF receptor associated factor-2 , NF-kappaB inducing kinase, and IkappaBalpha kinase, were all blocked by flavopiridol but not that activated by p65
Luftig et al., Proc Natl Acad Sci U S A 2003 : Epstein-Barr virus latent membrane protein 1 activation of NF-kappaB through IRAK1 and TRAF6 ... These data extend a role for IKKalpha in IKKbeta regulation, identify an unusual IKKbeta dependent and IKKgamma independent NF-kappaB activation, and indicate that IRAK1 and TRAF6 are essential for LMP1 induced NF-kappaB activation
Dickson et al., Dev Dyn 2004 : TRAF6 dependent NF-kB transcriptional activity during mouse development ... To assess the role of the TRAF6 adaptor protein in developmental NF-kB activity, we analyzed NF-kB activation in reporter mice rendered null for TRAF6
Xiong et al., J Biol Chem 2004 : Interaction of TRAF6 with MAST205 regulates NF-kappaB activation and MAST205 stability
Chen et al., Biochem Biophys Res Commun 2004 : Moreover, P6 induces MUC5AC transcription via TLR2-MyD88-IRAK1-TRAF6-TAK1 dependent p38 MAPK-AP1 and IKKbeta-IkappaBalpha-NF-kappaB signaling pathways
Hauer et al., Proc Natl Acad Sci U S A 2005 : Paradoxically, suppression of TRAF2/5 mediated NF-kappaB activation by TRAF3 resulted in enhanced transcriptional activity of TRAF6 mediated canonical NF-kappaB emanating from CD40
Ohishi et al., J Immunol 2005 (Bone Resorption) : In SOCS3-deficient BMMs, expression levels of TNF-receptor associated factor-6 and IkappaB were drastically reduced and receptor activator of the NF-kappaB ligand induced IkappaB phosphorylation was severely impaired in the presence of IL-6
Min et al., J Immunol 2005 : TNF related activation induced cytokine enhances leukocyte adhesiveness : induction of ICAM-1 and VCAM-1 via TNF receptor associated factor and protein kinase C-dependent NF-kappaB activation in endothelial cells
Bai et al., J Clin Invest 2005 (Arthritis...) : FHL2 inhibits TRAF6 induced NF-kappaB activity in wild-type osteoclast precursors and, in keeping with its role as a suppressor of TRAF6 mediated RANK signaling, TRAF6/RANK association is enhanced in FHL2-/- osteoclasts
Mashima et al., J Biol Chem 2005 : Furthermore, we demonstrated that NF-kappaB activation induced by TRAF6 and TAB2 was impaired by co-expression of FLN29, suggesting FLN29 may regulate the downstream of TRAF6
Shishodia et al., Cancer Res 2005 (Carcinoma, Small Cell...) : NF-kappaB dependent reporter gene expression was also suppressed by 4-HPR, as was NF-kappaB reporter activity induced by TNFR1, TRADD, TRAF2 , NIK, and IKK but not that induced by p65 transfection
Morlon et al., Hum Mol Genet 2005 (Ectodermal Dysplasia) : TAB2, TRAF6 and TAK1 are involved in NF-kappaB activation induced by the TNF-receptor, Edar and its adaptator Edaradd ... TAB2, TRAF6 and TAK1 are involved in NF-kappaB activation induced by the TNF-receptor, Edar and its adaptator Edaradd ... Moreover, we show that dominant negative forms of TAB2, TRAF6 and TAK1 blocked the NF-kappaB activation induced by Edaradd
Wu et al., J Biol Chem 2006 (Cell Transformation, Neoplastic) : Although the CTAR1 mediated NF-kappaB activation was previously shown to be TRAF3 dependent, we showed here that the CTAR2 mediated NF-kappaB activation is mainly TRAF6 dependent but TRAF2/5 independent
Conti et al., J Neurosurg 2005 (Brain Neoplasms...) : The authors investigated the expression of NF-kappaB , caspase 3, TRAF1, TRAF2, and TRAF associated NF-kappaB activator/TRAF interacting protein ( TANK/I-TRAF ), a regulator of TRAF activity, in human gliomas
Wang et al., Nat Immunol 2006 : Formation of the beta-arrestin-TRAF6 complex prevented autoubiquitination of TRAF6 and activation of NF-kappaB and AP-1
Maezawa et al., J Immunol 2006 (MAP Kinase Signaling System) : We also found that IL-25R mediated NF-kappaB activation was inhibited by the expression of dominant negative TRAF6 but not of dominant negative TRAF2 ... Taken together, these results indicate that TRAF6 plays a critical role in IL-25R mediated NF-kappaB activation and gene expression
He et al., J Biol Chem 2006 : TRAF6 regulates cell fate decisions by inducing caspase 8-dependent apoptosis and the activation of NF-kappaB
Song et al., Proc Natl Acad Sci U S A 2006 : Because IRAK1 is upstream of TRAF6 in IL-1 activation of NF-kappaB, the potential role of IRAK1 in LMP1 mediated NF-kappaB activation through TRAF6 and inhibitor of kappaB (IkappaB) kinase ( IKK ) was initially investigated
Minoda et al., Biochem Biophys Res Commun 2006 : We propose that ZCCHC11 is a unique TLR signal regulator, which interacts with TIFA after LPS treatment and suppresses the TRAF6 dependent activation of NF-kappaB
Chen et al., FEBS Lett 2006 : Hsp70 inhibits lipopolysaccharide induced NF-kappaB activation by interacting with TRAF6 and inhibiting its ubiquitination
Sethi et al., J Biol Chem 2006 : NF-kappaB reporter activity induced by TNFR1, TNF receptor associated death domain, TRAF2 , TAK1, NF-kappaB inducing kinase, and IKKbeta was inhibited by indirubin but not that induced by p65 transfection
Bidère et al., Curr Biol 2006 : Caspase-8 regulation by direct interaction with TRAF6 in T cell receptor induced NF-kappaB activation
Poole et al., EMBO J 2006 : The UL144 gene product of human cytomegalovirus activates NFkappaB via a TRAF6 dependent mechanism
Liuwantara et al., Diabetes 2006 : Activation of NF-kappaB by TNF receptor associated factor (TRAF) 2, TRAF6 , NF-kappaB inducing kinase, or protein kinase D, which transduce signals downstream of Toll-like receptors, TNF receptors, and free radicals, respectively, were all potent activators of the A20 promoter
Ryu et al., World J Gastroenterol 2006 (Hepatitis B) : During the initial state of HBV infection, hepatocytes facilitate the activation of NF-kappaB through up regulation of LT-alpha, TRAF2 , and NIK
Jackson-Bernitsas et al., Oncogene 2007 (Carcinoma, Squamous Cell...) : The expression of constitutively active NF-kappaB in HNSCC is mediated through the tumor necrosis factor (TNF) signaling pathway, as NF-kappaB reporter activity was inhibited by DN-TNF receptor associated death domain ( TRADD ), DN-TNF receptor associated factor (TRAF)2, DN-receptor interacting protein ( RIP ), DN-transforming growth factor-beta activated kinase 1 ( TAK1 ), DN-kappa-Ras, DN-AKT and DN-IKK but not by DN-TRAF5 or DN-TRAF6
Chang et al., J Biol Chem 2006 (Inflammation...) : An earlier study found that IL-17 activates NF-kappaB and MAPK pathways and requires TRAF6 to induce IL-6
Asagiri et al., Bone 2007 (Bone Resorption) : TRAF6 activates NF-kappaB , which is important for the initial induction of NFATc1
Hamazaki et al., Nat Immunol 2007 : We provide evidence that such Cld3,4 ( hi ) UEA-1 ( + ) TECs represented the initial progenitors specified for Aire ( + ) mTECs, whose development crucially required NF-kappaB inducing kinase and the adaptor molecule TRAF6
Noels et al., J Biol Chem 2007 (Lymphoma, B-Cell, Marginal Zone...) : In contrast, TRAF6 was essential for NF-kappaB activation by all fusion variants, and we identified a novel TRAF6 binding site in the second immunoglobulin domain of MALT1, which enhanced NF-kappaB activation when present in the fusion protein
Sung et al., Mol Pharmacol 2007 : NF-kappaB dependent reporter gene expression was also suppressed by fisetin, as was NF-kappaB reporter activity induced by TNFR1, TRADD, TRAF2 , NIK, and IKK but not that induced by p65 transfection
Sethi et al., Oncogene 2007 (Adenocarcinoma...) : Using dominant negative plasmids, we also demonstrated the role of TRADD, TRAF2 , NIK and Ras in EGF induced NF-kappaB activation
Chung et al., J Biochem Mol Biol 2007 : NF-kappaB activation by STP-C through the ubiquitinated TRAF6 causes the increased production of IL-8, an inflammatory chemokine and the enhanced expression of costimulatory molecule ICAM, which might ultimately contribute cellular transformation by the exposure of HVS infected cells with inflammatory microenvironment and chronic activation
Sethi et al., J Immunol 2007 : NF-kappaB reporter assay revealed that NF-kappaB activation induced by TNF, TNFR1, TRADD, TRAF2 , NIK, and I kappaB alpha kinase was modulated in gene deleted cells
Hostager et al., Immunol Res 2007 : TRAF6 contributes to the CD40 mediated activation of NF-kappaB , stress activated protein kinases, and perhaps other signaling molecules
Yang et al., J Biol Chem 2007 (Tuberculosis) : We also demonstrate a requirement for the E2-conjugating enzyme Ubc13, the E3 ubiquitin ligase Traf6 , and the ubiquitin activated kinase Tak1 in Nod2 mediated NF-kappaB activation
Huang et al., J Immunol 2007 : Requirement for both JAK mediated PI3K signaling and ACT1/TRAF6/TAK1 dependent NF-kappaB activation by IL-17A in enhancing cytokine expression in human airway epithelial cells
Zarnegar et al., Proc Natl Acad Sci U S A 2008 : Studies examining tumor-necrosis factor receptor associated factors ( TRAFs ) have identified positive roles for TRAF2, TRAF5 , and TRAF6, but not TRAF3, in canonical ( p50 dependent ) NF-kappaB activation ... Studies examining tumor-necrosis factor receptor associated factors ( TRAFs ) have identified positive roles for TRAF2, TRAF5, and TRAF6 , but not TRAF3, in canonical ( p50 dependent ) NF-kappaB activation
Hartupee et al., J Biol Chem 2008 : Surprisingly, although TRAF6 is essential for NFkappaB activation, it is not required for IL-1alpha induced mRNA stabilization
Bowie et al., Biochem Soc Trans 2008 : Further, I demonstrate how understanding one molecular mechanism whereby vaccinia virus inhibits NF-kappaB activation has led to a revealing of a key role for IRAK-2 in TRAF-6 mediated NF-kappaB activation
Ahmad et al., Blood 2008 : Altogether, these results unequivocally show that HSV-1 induces TLR2 dependent activation of IL-15 gene expression, which requires the recruitment of both MyD88 and TIRAP/Mal and the activation of IRAK1 and TRAF6 leading to NF-kappaB translocation to the nucleus
Sethi et al., Biochem Pharmacol 2008 (Neoplasm Invasiveness) : This led to suppression of the phosphorylation and translocation of p65 and also of NF-kappaB reporter activity induced by TNFR1, TRADD, TRAF2 , NIK, and IKKbeta but not that induced by p65 transfection
Blackwell et al., Mol Cell Biol 2009 (Lymphoma) : Notably, TRAF2 phosphorylation increased both basal and inducible c-Jun and NF-kappaB activities and rendered cells resistant to stress induced apoptosis
Yoshida et al., J Biol Chem 2008 (MAP Kinase Signaling System) : These data suggest that IPS-1 requires TRAF6 and MEKK1 to activate NF-kappaB and mitogen activated protein kinases that are critical for the optimal induction of type I interferons
Funakoshi-Tago et al., Cytokine 2009 : TRAF6 negatively regulates TNFalpha induced NF-kappaB activation ... Thus, these data suggest that TRAF6 negatively regulates TNFalpha induced NF-kappaB activation through its ubiquitin ligase activity
Walsh et al., PloS one 2008 (MAP Kinase Signaling System) : Further, this NEMO modification contributes to TRAF6 mediated activation of NFkappaB
Hartupee et al., J Immunol 2009 : Although overexpression of TRAF6 in HeLa cells activates NF-kappaB , it does not stabilize transfected KC mRNA
Verstak et al., J Biol Chem 2009 (Bacterial Infections...) : MyD88 adapter-like (Mal)/TIRAP interaction with TRAF6 is critical for TLR2- and TLR4 mediated NF-kappaB proinflammatory responses ... Furthermore, Mal interaction with TRAF6 mediates Ser phosphorylation of the p65 subunit of NF-kappaB and thus controls transcriptional activation but not nuclear translocation of NF-kappaB
Graham et al., J Immunol 2009 : Examination of TRAF binding, degradation, cytokine production, IgM secretion, and the activation of c-Jun kinase and NF-kappaB revealed that some events are dictated by TRAF binding site sequences, others are partially regulated, and still others are independent of the TRAF binding site sequence
Yamazaki et al., Science signaling 2009 : After TAK1 mediated activation of NF-kappaB, TRAF6 subsequently activated NF-kappaB through MEKK3 independently of TAK1, thereby establishing continuous activation of NF-kappaB, which was required for the production of sufficient cytokines
Manna et al., J Biol Chem 2010 : It inhibits TRAF2 mediated NF-kappaB activation but not TRAF6 mediated NF-kappaB DNA binding by preventing its association with TANK ( TRAF for NF-kappaB )
Bardag-Gorce et al., Exp Mol Pathol 2010 (Disease Models, Animal...) : TRAF-6 activation leads to activation of NFkB and the mitogen activated protein kinase ( MAPK ) cascade
Yoboua et al., J Virol 2010 : Respiratory syncytial virus mediated NF-kappa B p65 phosphorylation at serine 536 is dependent on RIG-I, TRAF6 , and IKK beta
Meads et al., J Immunol 2010 : We demonstrate that NF-kappaB activation by beta ( c ) is dependent on TNFR associated factor 6 (TRAF6) and that association of TRAF6 with beta ( c ) requires a consensus binding motif found in other molecules known to interact with TRAF6
Tewari et al., Curr Opin Genet Dev 1996 : Significantly, TRAF2 mediates the activation of NF-kappa B by both receptors
Cao et al., Nature 1996 : When overexpressed in human 293 cells, TRAF6 activates NF-kappaB
Duckett et al., Mol Cell Biol 1997 : TRAF dependent induction of NF-kappaB appears to be regulated by the relative levels of individual TRAF proteins in the cell
Kashiwada et al., J Exp Med 1998 : Here we report that transient expression of TRAF6 stimulated both ERK and NF kappa B activity in the 293 cell line
Geleziunas et al., Mol Cell Biol 1998 (Cell Transformation, Viral...) : However, plasma membrane-proximal elements in these proinflammatory cytokine pathways are apparently not involved since dominant negative mutants of the TRAF2 and TRAF6 adaptors, which effectively block signaling through the cytoplasmic tails of the TNF-alpha and IL-1 receptors, respectively, do not inhibit Tax induction of NF-kappaB
Wong et al., J Biol Chem 1998 : Dominant negative forms of TRAF2, TRAF5 , and TRAF6 and an endogenous inhibitor of TRAF2, TRAF interacting protein (TRIP), substantially inhibited TRANCE-R mediated NF-kappaB activation, suggesting a role of TRAFs in regulating DC and osteoclast function ... Dominant negative forms of TRAF2, TRAF5, and TRAF6 and an endogenous inhibitor of TRAF2, TRAF interacting protein (TRIP), substantially inhibited TRANCE-R mediated NF-kappaB activation, suggesting a role of TRAFs in regulating DC and osteoclast function
Galibert et al., J Biol Chem 1998 : An NH2-terminal truncation mutant of TRAF6 inhibited RANKL mediated NF-kappaB activation, but failed to affect constitutive signaling induced by receptor overexpression, revealing a selective role for TRAF6 in ligand induced activation events
Heyninck et al., FEBS Lett 1999 : Gene induction by IL-1 is mediated by activation of the transcription factor NF-kappaB , and requires the signal adapter protein TRAF6
Tsukamoto et al., Proc Natl Acad Sci U S A 1999 : However, single aa substitution of Glu-235 in cyt-N of human CD40 with Ala abolishes the binding of TRAF6 to cyt-N and NFkappaB activation by cyt-N