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HRAS — RELA

Text-mined interactions from Literome

Madrid et al., Mol Cell Biol 2000 : In this study, we show that oncogenic H-Ras requires PI3K and Akt to stimulate the transcriptional activity of NF-kappaB
Misra et al., Arch Biochem Biophys 2001 (Calcium Signaling...) : We conclude that alpha2M* induced cPLA2 synthesis is controlled by [ Ca2+ ] i levels, tyrosine kinase activity, the p21ras dependent MAPK and PI 3-kinase downstream signaling pathways, and regulation of NFkappaB
Bhat-Nakshatri et al., Oncogene 2002 (Breast Neoplasms) : Using breast cancer cell lines derived from transgenic mice that overexpress specific oncogene/growth factors in the mammary gland, we show that heregulin but not her2/neu, c-Myc or v-Ha-ras plays a major role in constitutive NF-kappaB activation
Millán et al., Oncogene 2003 : H-Ras-specific activation of NF-kappaB protects NIH 3T3 cells against stimulus dependent apoptosis
Na et al., J Immunol 2004 (Arthritis, Experimental) : Inhibition of farnesyltransferase prevents collagen induced arthritis by down-regulation of inflammatory gene expression through suppression of p21(ras) dependent NF-kappaB activation ... Together, these findings reveal that the inhibitory effect of LB42708 on p21(ras) dependent NF-kappaB activation may have potential therapeutic value for arthritis and other inflammatory diseases
Lee et al., Ann N Y Acad Sci 2004 : We also found that CAPE significantly inhibited H-ras induced NF-kappaB DNA binding activity without affecting the activation of extracellular signal regulated kinase and p38 mitogen activated protein kinase, which are major intracellular molecules involved in the Ras signaling pathways
Lee et al., Int J Cancer 2006 (MAP Kinase Signaling System) : DNA binding activity of nuclear factor (NF)-kappaB , but not that of activator protein (AP)-1, was increased by H-Ras
Yoon et al., Mol Cancer Ther 2006 (Breast Neoplasms...) : H-Ras did not increase MMP-9 in the presence of a PI3K inhibitor, LY294002, and a NF-kappaB inhibitor, SN50
Ghosh et al., J Neurosci 2009 (Disease Models, Animal...) : Inhibition of MPP ( + ) -induced activation of NF-kappaB by Deltap21 ( ras ), a dominant negative mutant of p21(ras), supported the involvement of p21(ras) in MPP ( + ) -induced microglial activation of NF-kappaB
Denko et al., Int J Oncol 1997 : Gel shift analysis and reporter gene expression indicated that TPCK blocked Ha-ras induced NF-kappa B activity, while only having minimal effects on Ha-ras induced AP-1 activity ... TPCK is therefore able to Inhibit the Ha-ras transformed phenotype of cells by inhibiting the transcriptional activity of NF-kappa B , while having little effect upon transcriptional activity of AP-1
Williams et al., Eur J Immunol 1995 : Reporter gene experiments demonstrated that NF-kappa B transcriptional activity is not affected by expression of activated p21ras
Folgueira et al., J Virol 1996 : Constitutively active p21ras ( v-H-Ras ) activated NF- kappa B-dependent transcription and induces the nuclear translocation of a bona fide p65/p50 heterodimer by targeting I kappa B alpha
Finco et al., J Biol Chem 1997 (Cell Transformation, Neoplastic) : Oncogenic Ha-Ras induced signaling activates NF-kappaB transcriptional activity, which is required for cellular transformation ... We show here that oncogenic forms of Ha-Ras activate NF-kappaB , not through induced nuclear translocation, but rather through the activation of the transcriptional function of the NF-kappaB RelA/p65 subunit