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IRS1 — RELA
Text-mined interactions from Literome
Kuo et al., Oncogene 2007
:
We conclude that the recruitment of
IRS-1 to activated ALK and the
activation of
NF-kappaB are essential for the autocrine growth and survival signaling of MK
Nishiumi et al., Toxicological sciences : an official journal of the Society of Toxicology 2010
(Insulin Resistance) :
TCDD also stimulated the phosphorylation of extracellular signal regulated kinase ( ERK ) 1/2 and c-Jun N-terminal kinase (JNK), and their inhibitors abrogated the TCDD induced downregulation of IRbeta,
IRS1 , and GLUT4 ; upregulation of TNF-alpha ; and
activation of
NF-kappaB
Jain et al., Mol Nutr Food Res 2010
(Diabetes Mellitus, Type 2...) :
While CDN and CP had no effect, activation of
NFkappaB , Akt and glucose transporter-2 levels were decreased,
insulin receptor substrate 1 (IRS-1) activation
increased in livers of CDNC-rats ... CDNC is a potent hypoglycemic compound with anti-inflammatory activity apparently mediated by elevated blood vitamin C and adiponectin and inhibition of
NFkappaB , Akt, and Glut-2 and increased
IRS-1 activation in livers of type 2 diabetic rats