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BCL6 — GRAP2
Text-mined interactions from Literome
Lakics et al., J Immunol 2000
:
More strikingly, LPS induced phosphorylation of
p38 mitogen activated protein kinase and c-Jun N-terminal kinase was strongly
repressed by
Bcl-xL overexpression, offering a possible mechanism for the inhibition of LPS induced cytokine production
Takata et al., Proc Natl Acad Sci U S A 2008
(Atherosclerosis...) :
In vitro studies demonstrated similar changes in AngII treated macrophages : PPARdelta activation increased both total and free
Bcl-6 levels and
inhibited AngII activation of MAP kinases,
p38 , and ERK1/2
Wang et al., Chin J Physiol 2007
:
Scutellarin decreased caspase-3 activity, increased
Bcl-XL expression,
inhibited p38 phosphorylation and attenuated ROS production
Chen et al., Toxicology 2009
(Neuroblastoma) :
SB202190 (
p38 MAPK inhibitor ) and SP600125 ( JNK inhibitor )
attenuated mitochondrial depolarization, degradation of
Bcl-2/Bcl-xL , and mitochondrial translocation of Bax
Harnett et al., Cell Biochem Funct 2013
:
Interestingly,
Bcl-xL expression
inhibited p38 activation, but Z-VAD-fmk treatment did not, indicating that activation of this MAPK occurs downstream of mitochondrial dysfunction and is independent of caspases