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HGF — PTGS2

Text-mined interactions from Literome

Grossman et al., Carcinogenesis 2000 (Gallbladder Neoplasms) : Employing a human gall bladder cancer cell line, mitogenesis, apoptosis and prostaglandin E ( 2 ) ( PGE ( 2 ) ) formation were evaluated in response to serum and hepatocyte growth factor and transforming growth factor alpha stimulation in the presence and absence of specific COX-1 and -2 inhibitors
Nakao et al., Mol Cell Biochem 2000 : These results suggest that NFkappaB is an important transcription factor for IL-1beta induced COX-2 gene expression, and is involved in inducing COX-2 gene transcription through tyrosine phosphorylation in HGF
Nomi et al., Biochem Biophys Res Commun 2000 (Liver Failure) : Expression of Bcl-xL and cyclooxygenase-2 (Cox-2) was induced in liver by HGF gene transfer
Shimada et al., Life Sci 2000 : In the present study, we examined whether hepatocyte growth factor (HGF) induced COX-2 affects ceramide induced apoptosis in RGM-1 gastric epithelial cells ... Application of HGF rapidly induced the expression of COX-2 , and HGF prevented the apoptotic cell death induced by C2-ceramide
Zeng et al., J Biol Chem 2002 (Carcinoma, Squamous Cell...) : Using a combination of microarray analysis and Northern blot analysis, we found that an anti-apoptotic gene cyclooxygenase-2 (cox-2) was induced by HGF in an activator protein-1 dependent fashion
Aoki et al., Oral Oncol 2006 (Adenoma, Pleomorphic...) : It is suggested that COX-2 expression may induce HGF expression in salivary gland tumors
Zhang et al., American journal of physiology. Renal physiology 2006 (Fibrosis...) : COX-2 induction by HGF was preceded by activation of ERK1/2, and an ERK1/2-specific inhibitor, U-0126 ( 10 microM ), completely abolished HGF induced COX-2 expression
Siegfried et al., Mol Pharmacol 2007 (Carcinoma, Non-Small-Cell Lung...) : Signaling pathways involved in cyclooxygenase-2 induction by hepatocyte growth factor in non small-cell lung cancer ... We examined four c-Met positive non-small-cell lung cancer ( NSCLC ) cell lines for effects of HGF on COX-2 ... HGF increased COX-2 protein expression 3-fold over basal levels
Kanayama et al., Oncol Rep 2008 (Endometrial Neoplasms) : Our data suggest that HGF induces anoikis resistance in endometrial cancer cells possibly through PI3K/Akt pathway dependent up-regulation of COX-2 expression
Lee et al., Am J Physiol Lung Cell Mol Physiol 2008 : Hepatocyte growth factor regulates cyclooxygenase-2 expression via beta-catenin, Akt, and p42/p44 MAPK in human bronchial epithelial cells ... Here, we report that HGF induces gene transcription of COX-2 in human bronchial epithelial cells ( HBEpC ) ... The HGF activation of the COX-2 gene transcription was blocked by DN mutant of beta-catenin or by inhibitors that blocked activation of Akt ... Together, the results show that the HGF increases COX-2 gene expression via an Akt-, MAPK-, and beta-catenin dependent pathway in HBEpC
Scarpino et al., J Pathol 2009 (Carcinoma, Papillary...) : COX-2 is induced by HGF stimulation in Met positive thyroid papillary carcinoma cells and is involved in tumour invasiveness ... Specific involvement of the high-affinity HGF receptor ( Met protein ) was suggested by the observation that PHA-665752, an inhibitor of the catalytic activity of c-Met kinase, caused a 54 % reduction of the hepatocyte growth factor induced COX-2 up-regulation
Yoshizawa et al., Oncol Rep 2011 (Endometrial Neoplasms) : Signaling pathway involved in cyclooxygenase-2 up-regulation by hepatocyte growth factor in endometrial cancer cells
Zhang et al., PloS one 2013 : Further, the treatment of tendon cell cultures with HGF antibodies reduced the suppressive effects of PRP or HGF on IL-1ß induced COX-1, COX-2 , and mPGES-1 gene expressions
Horie-Sakata et al., J Clin Gastroenterol 1998 (Stomach Ulcer) : HGF also induced expression of COX-2 protein in RGM-1 cells, and wounding itself induced COX-2 expression in the cells located at the edge of the wound