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IL2 — ODC1
Text-mined interactions from Literome
Wang et al., Anticancer Res 2002
(MAP Kinase Signaling System) :
We demonstrated that PA inhibited
ODC activity
induced by
IL2 in a time- and dose dependent manner
McCarthy et al., Immunopharmacology 1990
:
To examine the mechanism of action of DFMO, we studied the
effect of this
ODC inhibitor on lymphokine production and
interleukin 2 (IL 2) receptor expression ... Concentrations of IL 2 increased 7-fold in DFMO treated, PHA stimulated PBMC cultures, compared with untreated cells ; whereas
IL 2 receptor expression as measured by the anti-Tac monoclonal antibody was not
affected by the inhibition of
ODC
Legraverend et al., Exp Cell Res 1989
:
These findings suggest that the
regulation of the
ODC activity by
IL-2 is a primary event in IL-2 induced cell proliferation and occurs at the post-transcriptional level, possibly by stabilizing the ODC mRNA and affecting the efficiency of translation of the messenger
Legraverend et al., Exp Cell Res 1989
:
H-7, a potent inhibitor of PKC and cyclic nucleotide dependent protein kinases ( CN-PK ), suppressed the
IL-2 induced
ODC activity, while HA1004, a more potent inhibitor of CN-PK than of PKC, had opposite effects depending on its concentration ... The results suggest that activation of PKC is involved in but is not the sole mechanism for the
induction of
ODC by rec
IL-2
Farrar et al., J Immunol 1988
:
IL-2 regulates the expression and activation of the principal rate limiting enzyme of polyamine synthesis,
ornithine decarboxylase (ODC)
Fidelus et al., J Immunol 1984
:
Interleukin 2 (IL 2) and IL 2-containing supernatants were also capable of
increasing ODC activity in T lymphocytes in the absence of monocytes
Fidelus et al., Transplantation 1984
:
We conclude that ( 1 ) the induction of ODC in human lymphocytes by mitogen and alloantigen is inhibited in the presence of cyclosporine ; ( 2 ) the induction of ODC activity in purified T lymphocytes requires the presence of both mitogen and monocytes or their products ; ( 3 ) IL-1 and
IL-2 can supplement for monocytes and augment the phytohemagglutinin induction of ODC in T lymphocytes ; and ( 4 ) cyclosporine
inhibits ODC induction in T lymphocytes stimulated with mitogen in the added presence of monocytes, IL-1, or IL-2