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MAP2K1 — WNK1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Vitari et al., Biochem J 2004
(Hypertension...) :
Consistent with PKB mediating this phosphorylation, inhibitors of PI 3-kinase ( phosphoinositide 3-kinase ; wortmannin and LY294002 ) but not inhibitors of mammalian target of rapamycin ( rapamycin ) or
MEK1 ( mitogen activated protein kinase kinase-1 ) activation ( PD184352 ),
inhibited IGF1 induced phosphorylation of endogenous
WNK1 at Thr-60
Yang et al., J Cell Physiol 2010
(Arthritis, Rheumatoid) :
IL-1beta induced ICAM-1 expression, extracellular signal regulated kinase ( ERK ) and c-Jun-N-terminal kinase (JNK) phosphorylation, AP-1 activation, and nuclear factor-kappaB (NF-kappaB)
p65 translocation were
attenuated by the inhibitors of
MEK1/2 ( U0126 ), JNK ( SP600125 ), AP-1 ( tanshinone IIA ), and NF-kappaB ( helenalin ) or transfection with respective short hairpin RNA plasmids