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RHO — WNT16

Text-mined interactions from Literome

Habas et al., Cell 2001 : Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1 ... Here we report that in human cells and during Xenopus embryogenesis, Wnt/Fz signaling activates the small GTPase Rho , a key regulator of cytoskeleton architecture ... Wnt/Fz activation of Rho requires the cytoplasmic protein Dishevelled ( Dvl ) and a novel Formin homology protein Daam1 ... Daam1 binds to both Dvl and Rho, and mediates Wnt induced Dvl-Rho complex formation ... Inhibition or depletion of Daam1 prevents Wnt/Fz activation of Rho and of Xenopus gastrulation, but not of beta-catenin signaling
Habas et al., Genes Dev 2003 : We demonstrated previously that Wnt/Fz activation of Rho , a GTPase and regulator of cytoskeletal architecture, is essential for vertebrate gastrulation ... Dishevelled ( Dvl ), a cytoplasmic protein downstream of Fz, forms a Wnt induced complex with Rac independent of the Wnt induced Dvl-Rho complex
Habas et al., Methods Enzymol 2006 : Activation of Rho and Rac by Wnt/frizzled signaling ... In this chapter, we describe biochemical assays for the detection of Wnt/Fz activation of Rho and Rac in both mammalian cells and Xenopus embryo explants
Mezzacappa et al., Methods Mol Biol 2012 : The Rho family of small GTPases are activated and required for non-canonical Wnt signaling during gastrulation, and in this chapter, we describe biochemical assays for the detection of Wnt mediated activation of Rho , Rac, and Cdc42 in both mammalian cells and Xenopus embryo explants
Bannai et al., Frontiers in cellular and infection microbiology 2012 : Our results reveal new details of the pathways involved in dermonecrotic toxin action on adipocyte differentiation, and the role of Rho/ROCK signaling in mediating toxin effects on Wnt/ß-catenin and Notch1 signaling, and in particular the role of G ( q ) and G ( 12/13 ) in mediating PMT effects on Rho/ROCK and Notch1 signaling