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IL10 — NOD2

Text-mined interactions from Literome

Gandotra et al., Infect Immun 2007 (Tuberculosis) : Mycolylarabinogalactan peptidoglycan ( PGN ), the cell wall core of M. tuberculosis, stimulated macrophages to release tumor necrosis factor (TNF) and interleukin-12p40 in a partially NOD2 dependent manner, and M. tuberculosis PGN required NOD2 for the optimal induction of TNF
Samson et al., Inflamm Bowel Dis 2011 (Crohn Disease...) : Both GM-CSF neutralization and Card15 deficiency were required for downregulation of MLN DC IL-10 expression ; under these conditions NSAID exposure led to an expansion of IL-4 ( + ) and IL-17 ( + ) CCR9 ( + ) lymphocytes in the ileum
Yu et al., PloS one 2011 (Lupus Erythematosus, Systemic) : Down regulated NOD2 by immunosuppressants in peripheral blood cells in patients with SLE reduces the muramyl dipeptide induced IL-10 production
Oh et al., PLoS Pathog 2013 (Sepsis) : Furthermore, we found that NOD2 mediated IL-10 production by neutrophils enhanced C5a generation by suppressing CD55 expression on neutrophils in IL-1ß dependent and/or IL-1ß independent manners, thereby aggravating CLP induced sepsis