◀ Back to POU5F1

POU5F1 — WWP2

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: WWP2 — POU5F1 (physical association, affinity chromatography technology) Qian et al., Gastroenterology 2012*
• IRef Biogrid Interaction: WWP2 — POU5F1 (physical association, affinity chromatography technology) Xu et al., Cell Res 2009*
• IRef Biogrid Interaction: WWP2 — POU5F1 (direct interaction, pull down) Xu et al., Cell Res 2009*
• IRef Biogrid Interaction: WWP2 — POU5F1 (direct interaction, enzymatic study) Xu et al., Cell Res 2009*
• IRef Intact Interaction: WWP2 — POU5F1 (physical association, anti bait coimmunoprecipitation) Xu et al., Cell Res 2009*
• IRef Intact Interaction: WWP2 — POU5F1 (physical association, anti tag coimmunoprecipitation) Xu et al., Cell Res 2009*
• IRef Intact Interaction: WWP2 — POU5F1 (direct interaction, pull down) Xu et al., Cell Res 2009*
• IRef Intact Interaction: Complex of POU5F1-WWP2-UBE2E1 (ubiquitination reaction, ubiquitinase assay) Xu et al., Cell Res 2009*

Text-mined interactions from Literome

Xu et al., J Biol Chem 2004 : Furthermore, overexpression of Wwp2 in embryonic stem cells significantly reduces the Oct-4-transcriptional activities
Xu et al., Cell Res 2009 : WWP2 promotes degradation of transcription factor OCT4 in human embryonic stem cells ... Here, we report that human WWP2 , an E3 ubiquitin (Ub)-protein ligase, interacts with OCT4 specifically through its WW domain and enhances Ub modification of OCT4 both in vitro and in vivo ... Furthermore, we found that WWP2 promoted degradation of OCT4 through the 26S proteasome in a dosage dependent manner, and the active site cysteine residue of WWP2 was required for both its enzymatic activity and proteolytic effect on OCT4
Liao et al., Cell Res 2010 : However, roles of Wwp2 in regulating endogenous Oct4 protein levels as well as molecular characteristics of the function of Wwp2 have not been determined ... Here, we report that Wwp2 plays an important role in Oct4 ubiquitination and degradation during differentiation of embryonal carcinoma cells ( ECCs ), although it does not appear to affect Oct4 protein levels in the undifferentiated ECCs and ESCs ... Taken together, these results demonstrate a crucial role of Wwp2 in controlling endogenous Oct4 protein levels during differentiation processes of ECCs and suggest an interesting dosage dependent mechanism for regulating the catalytic activity of the E3 ubiquitin ligase, Wwp2