◀ Back to GP6
GP6 — XRCC5
Text-mined interactions from Literome
Larson et al., Blood 2003
:
Because activation of Rap1, an abundant small guanosine triphosphatase ( GTPase ) in platelets, contributes to integrin alpha ( IIb ) beta ( 3 ) activation, we asked whether and how
GPVI signaling
activates Rap1 in platelets ... Using a reconstituted system in RBL-2H3 cells, we found that
GPVI mediated
Rap1 activation is dependent on FcRgamma but independent of another platelet collagen receptor, alpha ( 2 ) beta ( 1 ) ... Interestingly,
GPVI mediated
Rap1 activation in human platelets is largely dependent on adenosine diphosphate ( ADP ) signaling through the P2Y(12) and not the P2Y(1) receptor ... However, experiments with specific ADP receptor antagonists and platelets from knockout mice deficient in P2Y(1) or the P2Y(12) associated G-protein, Galphai ( 2 ), indicate that human and murine platelets also have a significant P2Y(12) independent component of
GPVI mediated
Rap1 activation
Canobbio et al., Blood 2009
:
However, PI3Kbeta, but not PI3Kgamma, enzymatic activity was absolutely required for Akt phosphorylation,
Rap1 activation , and platelet aggregation downstream of the immunoreceptor tyrosine based activation motif ( ITAM ) -bearing receptor
glycoprotein VI (GPVI)
Gilio et al., J Biol Chem 2009
(Thrombosis) :
Furthermore, PI3Kalpha/beta, but not PI3Kgamma, contributed to
GPVI induced
Rap1b activation and, surprisingly, also to Rap1b independent platelet activation via GPVI