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RUNX1 — SMAD6

Text-mined interactions from Literome

Phimphilai et al., J Bone Miner Res 2006 : However, RUNX2 did not increase the ability of this BMP to activate SMAD , ERK, p38, and JNK pathways
Knezevic et al., Mol Cell Biol 2011 : Here we show that Runx1 , in conjunction with Fli1, Gata2, and Scl, directly regulates the expression of Smad6 in the aorta-gonad-mesonephros ( AGM ) region in the developing embryo, where HSCs originate ... Runx1 regulates Smad6 activity via a novel upstream enhancer, and Runx1 null embryos show reduced Smad6 transcripts in the yolk-sac and c-Kit positive fetal liver cells
Laronda et al., Dev Biol 2013 (Vaginal Diseases) : This SMAD dependent dNp63 activation required RUNX1 , a binding partner of SMADs