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BDNF — PI3
Text-mined interactions from Literome
Polleux et al., Development 2002
:
BDNF and NT4
cause rapid activation of
PI3-kinase in MGE cells, and inhibition of PI3-kinase ( but not of MAP kinase or PLCgamma ) dramatically attenuates tangential migration
Goggi et al., Brain Res 2003
:
Three proteins mediating signalling pathways are
activated by the binding of
BDNF to TrkB :
phosphoinositol-3 kinase (PI3K) ; Ras-MEK and phospholipase C-gamma ( PLCgamma )
Patz et al., Cereb Cortex 2004
:
The
BDNF action
required PI3 kinase signalling
Dijkhuizen et al., J Neurobiol 2005
:
BDNF leads to the rapid activation of PI3-kinase, MAP kinase, and PLC-gamma in cortical neurons, and pharmacological inhibition of
PI3-kinase and MAP kinase in dissociated cell cultures and cortical slice cultures
suppresses the ability of BDNF to induce dendrite formation
Leeds et al., Neurochem Int 2005
:
BDNF , but not NT-3, treatment of immature CGC
caused a marked, but transient activation of Akt through
phosphatidylinositol (PI) 3-kinase
Bogush et al., J Biol Chem 2007
(Huntington Disease) :
DARPP-32 induction by
BDNF in vitro
requires phosphatidylinositide 3-kinase (PI3K) , but inhibition of phosphorylation of protein kinase B/Akt does not entirely abolish expression of DARPP-32
Sun et al., Tumour Biol 2010
(Multiple Myeloma) :
Stimulation of MM cells with
BDNF led to the activation of the
phosphatidylinositol 3-kinase (PI3K)/Akt and the MEK-extracellular signal regulated protein kinase pathways
Cheng et al., Proc Natl Acad Sci U S A 2011
:
Second,
BDNF/TrkB signaling
activates PI3-kinase that promotes anterograde transport of TrkB in the putative axon, further enhancing local BDNF/TrkB signaling ... Second,
BDNF/TrkB signaling
activates PI3-kinase that promotes anterograde transport of TrkB in the putative axon, further enhancing local BDNF/TrkB signaling
Qiu et al., J Neurosci Res 1998
:
The purpose of this investigation was to examine the
effects of cationic lipid mediated gene transfection of
BDNF on
phosphatidylinositol 3 (PI3)-kinase activity in primary septo-hippocampal cell cultures