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EGF — STAT1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: Complex of PTPN11-STAT1 → EGF (increases) Wu et al., J Biol Chem 2002
  Evidence: SHP-2 and Stat1 nuclear localization and their association in response to either epidermal growth factor or interferon-gamma (IFNgamma) were confirmed by immunofluorescent staining and affinity precipitation assays.
• OpenBEL Selventa BEL large corpus: STAT1 → EGF (increases)
  Evidence: The positive control EGF did increase pSTAT1 levels (Fig. 5, row 1). Methods: pSTAT1 (Tyr701) (Cell Signaling Technology, Danvers, MA)
• BioCarta egf signaling pathway: EGF/EGF-R complex (EGF-EGFR) → STAT1 (modification, activates)

Text-mined interactions from Literome

Horiuchi et al., Circ Res 1999 : AT2 receptor activation also inhibited the tyrosine phosphorylation of STAT1alpha/beta induced by interferon-gamma, epidermal growth factor , and platelet derived growth factor
Guren et al., Biochem Biophys Res Commun 1999 : EGF induced activation of Stat1 , Stat3, and Stat5b is unrelated to the stimulation of DNA synthesis in cultured hepatocytes ... In freshly isolated hepatocytes, EGF activated Stat1 , Stat3, and, particularly, Stat5b ... In these cells EGF did not detectably activate Stat1 , Stat3, or Stat5b but markedly stimulated MAP kinase ( Erk1/2 )
Rebsamen et al., J Mol Cell Cardiol 2000 (Cardiomegaly) : EGF did not activate Stat1 and Stat3, but did induce a rapid and transient activation of Stat5, which corresponded mainly to Stat5b DNA binding
Tenev et al., Eur J Cell Biol 2000 : Perinuclear localization of the protein-tyrosine phosphatase SHP-1 and inhibition of epidermal growth factor stimulated STAT1/3 activation in A431 cells
Watanabe et al., Cancer J 2001 (Carcinoma, Squamous Cell...) : EGF can also activate STAT1 in cultured normal esophageal squamous epithelial cells
Vasilenko et al., Tsitologiia 2001 : Using a pharmacological inhibitor of Src kinases CGP77675 and cells with knockout c-src, it was shown that Src activated STAT1 upon stimulation by both epidermal growth factor and hypersomatic shock
Kasza et al., J Physiol Pharmacol 2002 (Astrocytoma...) : It was found that although EGF alone does not activate STAT1 , the STAT1 binding activity in the cells treated with the mixture of EGF/IFNgamma was considerably prolonged
Burova et al., Tsitologiia 2003 : [STAT1 and STAT3 activation by oxidative stress in A431 cells involves Src dependent EGF receptor transactivation ]
Wang et al., Free Radic Biol Med 2003 : Moreover, p38 MAPK and EGF receptor activation are required for V2O5 induced STAT-1 activation
Chen et al., Oncogene 2004 (Breast Neoplasms) : By contrast, a kinase domain deletion mutant EtkDeltaK, functioning as a dominant negative mutant, ameliorates EGF induced Stat1 activation and apoptosis in MDA-MB-468 cells
Vasilenko et al., Tsitologiia 2004 : Here, we have compared STAT1 and STAT3 activation in response to IFNgamma, IFNalpha and epidermal growth factor (EGF) in A431 cells ... We have shown the STAT1 activation by all these agents ; unlike, STAT3 was activated by EGF only
Zhang et al., Exp Eye Res 2005 : Retinas from embryonic and neonatal stages showed that STAT3 but not STAT1 was activated in response to ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), fibroblast growth factor-1 (FGF1), fibroblast growth factor-2 (FGF2), epidermal growth factor (EGF) , interferon-alpha ( IFN-alpha ) and interferon-gamma (IFN-gamma) in distinct patterns
Itoh et al., Oncogene 2006 (Urinary Bladder Neoplasms) : We report that STAT3, but not STAT1 and STAT5, becomes phosphorylated in response to epidermal growth factor (EGF) and achieves maximal induction of collagenase-1 ( MMP-1 ) transcription by interacting with c-JUN
Akl et al., Planta Med 2012 (Breast Neoplasms...) : Western blot studies revealed that combined low-dose treatment of ?-tocotrienol and sesamin caused a marked reduction in EGF induced ErbB3 and ErbB4 receptors phosphorylation ( activation ) and a relatively large decrease in intracellular levels of total and/or phosphorylated c-Raf, MEK1/2, ERK1/2, PI3K, PDK1, Akt, p-NF?B, Jak1, Jak2, and Stat1 , as compared to cells treated with only one compound or in the vehicle treated control group
Marra et al., J Clin Invest 1996 : However, IFN-gamma pretreatment markedly potentiated the DNA binding activity of STAT1alpha in response to PDGF or EGF
Xie et al., Anticancer Res 1997 (Breast Neoplasms) : Using electrophoretic mobility shift assays ( EMSA ), we found that EGF activates STAT1 and STAT3 in the MDA468 cells
Vasilenko et al., Tsitologiia 1997 (Carcinoma, Squamous Cell) : In has been shown that a prolonged presence of EGF induces a rapid tyrosine phosphorylation and nuclear translocation of Stat1 ( within 5 min )
Suzuki et al., Biochem Biophys Res Commun 1997 (Carcinoma, Squamous Cell) : Lysophosphatidic acid inhibits epidermal-growth-factor induced Stat1 signaling in human epidermoid carcinoma A431 cells ... We found that LPA inhibited epidermal growth factor (EGF) induced Stat1 activation in a concentration dependent manner ... These findings suggest that the inhibitory effect on EGF induced Stat1 activation may be a general characteristic of PLC coupled GPCRs and PKC pathway may be mainly associated with this inhibitory effect
Iwamoto et al., J Biol Chem 1998 : EGF activates STAT1 and STAT3 in A431 but not in HeLa and PC12 cells
Johnson et al., Am J Physiol 1999 : First, EGF promoted the tyrosine phosphorylation of STAT1 in IEC-6 cells and caused its translocation to the nucleus