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EGF — NRAS

Pathways - manually collected, often from reviews:

• NCI Pathway Database Internalization of ErbB1: RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS) → EGFR/EGFR/EGF/EGF/GRB2/SOS1 complex (EGFR-EGF-GRB2-SOS1) (modification, collaborate)
  Haugh et al., J Biol Chem 1999, Pennock et al., Mol Cell Biol 2003, Wiley et al., J Biol Chem 1991, Di Guglielmo et al., EMBO J 1994, Herbst et al., J Biol Chem 1994
  Evidence: assay
• NCI Pathway Database Internalization of ErbB1: EGFR/EGFR/EGF/EGF/GRB2/SOS1 complex (EGFR-EGF-GRB2-SOS1) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, activates)
  Haugh et al., J Biol Chem 1999, Pennock et al., Mol Cell Biol 2003, Wiley et al., J Biol Chem 1991, Di Guglielmo et al., EMBO J 1994, Herbst et al., J Biol Chem 1994
  Evidence: assay
• NCI Pathway Database Internalization of ErbB1: RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS) → EGFR/EGFR/EGF/EGF/p46 SHC/GRB2/SOS1 complex (EGFR-EGF-SHC1-GRB2-SOS1) (modification, collaborate)
  Haugh et al., J Biol Chem 1999
  Evidence: assay
• NCI Pathway Database Internalization of ErbB1: EGFR/EGFR/EGF/EGF/p46 SHC/GRB2/SOS1 complex (EGFR-EGF-SHC1-GRB2-SOS1) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, activates)
  Haugh et al., J Biol Chem 1999
  Evidence: assay
• NCI Pathway Database Internalization of ErbB1: RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS) → EGFR/EGFR/EGF/EGF/p52 SHC/GRB2/SOS1 complex (EGFR-EGF-SHC1-GRB2-SOS1) (modification, collaborate)
  Haugh et al., J Biol Chem 1999
  Evidence: assay
• Reactome Reaction: EGF → NRAS (reaction) Paez et al., Science 2004, Sordella et al., Science 2004, Shimamura et al., Cancer Res 2005, Janes et al., Oncogene 1994, Chardin et al., Science 1993, Xie et al., J Biol Chem 1995

Text-mined interactions from Literome

Giehl et al., Oncogene 2000 (Pancreatic Neoplasms) : Stimulation of cells with epidermal growth factor (EGF) or fetal calf serum ( FCS ) resulted in activation of N-Ras , but not K-Ras, as well as activation of c-Raf, MEK-1, and p42 MAPK
Kranenburg et al., Curr Biol 2001 (MAP Kinase Signaling System) : We find that epidermal growth factor (EGF) activates N-Ras but fails to activate K-Ras in these cells ... Extraction of cholesterol with methyl-beta-cyclodextrin disrupts complex formation between caveolin and K- and N-Ras and, strikingly, enables EGF to activate both K-Ras and N-Ras
van Houdt et al., Neoplasia (New York, N.Y.) 2010 (Colorectal Neoplasms) : Deletion of oncogenic KRAS not only resensitized tumor cells to EGFR inhibition but also promoted EGF induced NRAS activation, ERK and AKT phosphorylation, and c-FOS transcription
Eisenberg et al., Mol Cell Biol 2011 : HA-GPI clustering enhanced the Golgi compartment ( GC ) accumulation and signaling of epidermal growth factor (EGF) stimulated N-Ras-GTP