Gene interactions and pathways from curated databases and text-mining

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APP — PRKAR1A

Text-mined interactions from Literome

Westmark et al., Brain Res Mol Brain Res 2001 (MAP Kinase Signaling System) : However the protein kinase C ( PKC ), protein kinase A (PKA) or PLC pathways did not mediate these changes in APP mRNA levels
Cashman et al., Mol Chem Neuropathol 1995 (Alzheimer Disease) : The purpose of this study was to compare the effects of aging and Alzheimer disease (AD) on the important intracellular signaling enzyme cAMP dependent protein kinase A (PKA) in cerebral microvessels
Marambaud et al., J Neurochem 1996 : Altogether, this report demonstrates that the alpha-secretase pathway is under the control of PKA in human cells and that the proteasome likely contributes, either directly or through yet unknown intermediates, to the PKA stimulated APP alpha secretion in human cells