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CDKN1A — PLK1

Text-mined interactions from Literome

Salvatore et al., Cancer Res 2007 (Carcinoma...) : Adoptive overexpression of p53, p21 ( CIP1/WAF1 ), and E2F4 down-regulated transcription from the PLK1 and TTK promoters in ATC cells, suggesting that these genes might be under the negative control of tumor suppressors of the p53 and pRB families
Kreis et al., Cell cycle (Georgetown, Tex.) 2009 (Chromosome Aberrations) : Long-term downregulation of Polo-like kinase 1 increases the cyclin dependent kinase inhibitor p21 ( WAF1/CIP1 ) ... The data demonstrate that the long-term suppression of Plk1 increases the levels of cyclindependent kinase inhibitor p21 ( WAF1/CIP ), which is partially induced by the elevated tumor suppressor p73 in p53 inactivated HeLa cells
de Carné Trécesson et al., J Biol Chem 2011 : We also observed that p21 ( WAF1 ) prevents the expression of the CDC25A and PLK1 genes to induce cell cycle arrest
Seo et al., J Korean Med Sci 2011 (Prostatic Neoplasms) : In conclusion, flavonoids treatment induces up-regulation of p21 expression, and p21 inhibits transcription of PLK-1 , which promotes apoptosis of cancer cells