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IL2 — MALT1

Text-mined interactions from Literome

Maestroni et al., Adv Exp Med Biol 1999 : Activation of MLT receptors enhances the release of T-helper cell type 1 ( Th1 ) cytokines, such as gamma-interferon and interleukin-2 (IL-2) , as well as of novel opioid cytokines which crossreact immunologically with both interleukin-4 (IL-4) and dynorphin B. MLT has been reported also to enhance the production of interleukin-1 (IL-1), interleukin-6 (IL-6) and interleukin-12 (IL-12) in human monocytes
Ruland et al., Immunity 2003 (Lymphoma, B-Cell, Marginal Zone) : Using mouse models, we show that Malt1 is essential for T cell activation, proliferation, and IL-2 production in response to TCR ligation and strictly required for signal-specific NF-kappaB activation induced by the TCR but not TNF-alpha or IL-1 signaling
Sun et al., Mol Cell 2004 (Lymphoma, B-Cell, Marginal Zone) : RNAi mediated silencing of MALT1 , TAK1, TRAF6, and TRAF2 suppressed TCR dependent IKK activation and interleukin-2 production in T cells
Rebeaud et al., Nat Immunol 2008 : In contrast, MALT1 activity but not Bcl-10 cleavage was essential for optimal activation of transcription factor NF-kappaB and production of interleukin 2
Düwel et al., J Immunol 2009 : Using antagonistic peptides or reconstitution of Malt1 ( -/- ) T cells, we show that Malt1 paracaspase activity is required for A20 cleavage and optimal IL-2 production, but dispensable for initial IKK/NF-kappaB signaling in CD4 ( + ) T cells
Lissoni et al., Oncology 1994 (Neoplasms) : Our preliminary studies in humans have shown that the pineal neurohormone melatonin (MLT) may enhance the antitumor activity of IL-2 , by confirming the existence of a neuroendocrine control on cytokine effects