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MMP7 — STAT3
Text-mined interactions from Literome
Udayakumar et al., Prostate 2004
(Prostatic Neoplasms) :
Further, expression of dominant negative
STAT3 inhibited the FGF-1 induced transactivation of the human
MT1-MMP 7.2-kb promoter
Holnthoner et al., Biochem Biophys Res Commun 2006
:
Instead, we show that overexpression of a dominant negative
Stat3 mutant
reduces FGF-2 mediated
MMP7 promoter activity ... However,
Stat3 does not bind to the MMP7 promoter, but
activates MMP7 gene expression indirectly via AP-1
Pini et al., J Leukoc Biol 2012
(Inflammation...) :
However, the delayed resolution of neutrophil infiltration ; sustained production of CXCL1, CXCL2, and CCL2 ; prolonged
activation of
STAT-3 ; and induction of
MMP-7 in the pancreas, as well as heightened induction of serum amylase A of DIO mice, were blunted significantly in DIO IL-6 KO mice