◀ Back to STAT1
IRF7 — STAT1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Li et al., Mol Ther 2004
:
Intramuscular injection of the same Il-12 gene using electroporation upregulates Mig and
Stat1 by only 6- and 2.9-fold, respectively, but does not
induce any
IRF7 accumulation in the nuclei
Prakash et al., J Biol Chem 2005
:
We found that IFN produced locally in the respiratory tract of influenza virus infected mice displayed characteristics of positive feedback, including
Stat1 dependent induction of
IRF7 and IFN gene expression
Guo et al., J Immunol 2005
:
IRF-2 constitutively binds to the two ISRE/IRF-E sites at the DRR, while IRF-1 and
STAT1 are
induced to bind to the two
ISRE/IRF-E sites and the ISRE/IRF-E1, respectively, only after IFN-beta treatment
Huang et al., J Clin Invest 2007
(Inflammation...) :
Enforced expression of STAT1,
IRF-1 , or GATA-1
enhanced phosphorylation of
STAT1 , STAT3, and STAT5 in cultured Gata1-deficient murine megakaryocytes, with concomitant megakaryocyte maturation
Nguyen et al., Oncogene 1997
:
Most strikingly, induction of IRF-1 and
IRF/RelA expression
resulted in a significant increase in
STAT1 ( p91 ) protein and increased ISGF3 DNA binding activity, suggesting that IRF-1 tumor suppressor activity may involve a novel mechanism which activates the JAK-STAT pathway through STAT1