◀ Back to PTEN
MDM2 — PTEN
Text-mined interactions from Literome
Mayo et al., Trends Biochem Sci 2002
:
p53 acutely induces
Mdm2 , providing damaged cells the opportunity for repair, but subsequently
induces PTEN , favoring the death of mutated or irrevocably damaged cells
Zhou et al., Cancer Res 2003
(Burkitt Lymphoma...) :
These results suggest that
PTEN inhibits
MDM2 and protects p53 through both p13k/Akt dependent and -independent pathways
Zhong et al., Zhonghua Zhong Liu Za Zhi 2003
(Astrocytoma) :
To study the incidence of PTEN, Mdm2 and p53 expression in different histopathological grades of astrocytoma and the signal transduction mechanism through which
PTEN affects
Mdm2 and p53 expression
Bárdos et al., Mol Cell Biol 2004
:
We found that growth factor stimulation, overexpression of Akt/PKB, or loss of
PTEN resulted in enhanced expression of both HIF-1alpha and
HDM2
Chang et al., J Biol Chem 2004
:
PTEN regulates
Mdm2 expression through the P1 promoter ... Furthermore,
PTEN controls
Mdm2 P1 promoter activity through its lipid phosphatase activity, independent of p53
Mayo et al., J Biol Chem 2005
:
Induction of
PTEN by p53 followed by expression of PTEN
inhibits AKT induced translocation of
MDM2 into the nucleus and sustains p53 function
Selvendiran et al., J Biol Chem 2007
(Ovarian Neoplasms) :
The up-regulation of
PTEN inhibited Akt and
MDM2 , which enhanced the level of p53, thereby inducing G ( 2 ) /M arrest and apoptosis
Mitra et al., J Cell Mol Med 2009
(Graft Occlusion, Vascular...) :
However,
PTEN overexpression
had no significant effect on
MDM2 and p53 expression in IMA SMCs. PTEN overexpression inhibited IGF-1 induced SMC proliferation in both SV and IMA
Zheng et al., J Cell Biochem 2010
(Stomach Neoplasms) :
FTY720 dramatically increased the expression of Cip1/p21, p27, and BH3-only proteins through the accumulation of p53 by
PTEN mediated inhibition of the
PI3K/Akt/MDM2 signaling ... Furthermore, we have observed an additive effect of FTY720 in killing gastric cancer cells when in combination with Cisplatin, partly through
PTEN mediated
Akt/MDM2 inhibition