◀ Back to GRB2
CSF2 — GRB2
Pathways - manually collected, often from reviews:
-
NCI Pathway Database GMCSF-mediated signaling events:
GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/GAB2 complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-CSF2-CSF2RA)
→
GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/GAB2/PI3K complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-CSF2-CSF2RA-PIK3CA-PIK3R1)
(modification, collaborate)
Dijkers et al., Oncogene 1999, Gu et al., Mol Cell Biol 2000, Guthridge et al., EMBO J 2006, Sato et al., EMBO J 1993
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database GMCSF-mediated signaling events:
GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/GAB2 complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-CSF2-CSF2RA)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, collaborate)
Dijkers et al., Oncogene 1999, Gu et al., Mol Cell Biol 2000, Guthridge et al., EMBO J 2006, Sato et al., EMBO J 1993
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database GMCSF-mediated signaling events:
GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/GAB2/PI3K complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-CSF2-CSF2RA-PIK3CA-PIK3R1)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, collaborate)
Dijkers et al., Oncogene 1999, Gu et al., Mol Cell Biol 2000, Guthridge et al., EMBO J 2006, Sato et al., EMBO J 1993
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database GMCSF-mediated signaling events:
GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA)
→
GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/SOS1 complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA-GRB2-SOS1)
(modification, collaborate)
Piu et al., Oncogene 2002, Lanfrancone et al., Oncogene 1995
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database GMCSF-mediated signaling events:
GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA)
→
GRB2/SOS1 complex (GRB2-SOS1)
(modification, collaborate)
Piu et al., Oncogene 2002, Lanfrancone et al., Oncogene 1995
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database GMCSF-mediated signaling events:
GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/SOS1 complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA-GRB2-SOS1)
→
GRB2/SOS1 complex (GRB2-SOS1)
(modification, collaborate)
Piu et al., Oncogene 2002, Lanfrancone et al., Oncogene 1995
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database GMCSF-mediated signaling events:
GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/SOS1 complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA-GRB2-SOS1)
→
None
(modification, activates)
Piu et al., Oncogene 2002, Guthridge et al., Blood 2004, Lanfrancone et al., Oncogene 1995, Sato et al., EMBO J 1993
Evidence: mutant phenotype, assay
-
NCI Pathway Database GMCSF-mediated signaling events:
GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/SOS1 complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA-GRB2-SOS1)
→
RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS)
(modification, activates)
Piu et al., Oncogene 2002, Guthridge et al., Blood 2004, Lanfrancone et al., Oncogene 1995, Sato et al., EMBO J 1993
Evidence: mutant phenotype, assay
-
NCI Pathway Database GMCSF-mediated signaling events:
GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/SOS1 complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA-GRB2-SOS1)
→
RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS)
(modification, activates)
Piu et al., Oncogene 2002, Guthridge et al., Blood 2004, Lanfrancone et al., Oncogene 1995, Sato et al., EMBO J 1993
Evidence: mutant phenotype, assay
-
NCI Pathway Database GMCSF-mediated signaling events:
GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/SOS1 complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA-GRB2-SOS1)
→
None
(modification, activates)
Piu et al., Oncogene 2002, Guthridge et al., Blood 2004, Lanfrancone et al., Oncogene 1995, Sato et al., EMBO J 1993
Evidence: mutant phenotype, assay
-
NCI Pathway Database GMCSF-mediated signaling events:
GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA)
→
GRB2/GAB2 complex (GRB2-GAB2)
(modification, collaborate)
Gu et al., Mol Cell Biol 2000
Evidence: mutant phenotype
-
NCI Pathway Database GMCSF-mediated signaling events:
GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA)
→
GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/GAB2 complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-CSF2-CSF2RA)
(modification, collaborate)
Gu et al., Mol Cell Biol 2000
Evidence: mutant phenotype
-
NCI Pathway Database GMCSF-mediated signaling events:
GRB2/GAB2 complex (GRB2-GAB2)
→
GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/GAB2 complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-CSF2-CSF2RA)
(modification, collaborate)
Gu et al., Mol Cell Biol 2000
Evidence: mutant phenotype
-
Reactome Reaction:
CSF2
→
GRB2
(reaction)
Harmer et al., J Biol Chem 1999, Rozakis-Adcock et al., Nature 1992, Ravichandran et al., J Biol Chem 1994, Odai et al., Blood 1997
-
Reactome Reaction:
CSF2
→
GRB2
(indirect_complex)
Harmer et al., J Biol Chem 1999, Rozakis-Adcock et al., Nature 1992, Ravichandran et al., J Biol Chem 1994, Odai et al., Blood 1997
Text-mined interactions from Literome
Welham et al., J Biol Chem 1994
:
Interleukin (IL)-3 and granulocyte/macrophage
colony stimulating factor , but not IL-4,
induce tyrosine phosphorylation, activation, and association of SHPTP2 with
Grb2 and phosphatidylinositol 3'-kinase
Hanazono et al., Acta Haematol 1996
:
Furthermore, we have shown that the proto-oncogene c-cbl product (c-Cbl) is also tyrosine phosphorylated by
stimulation with
GM-CSF or Epo and is constitutively associated with the SH3 domain of
Grb2/Ash in UT-7
Shi et al., Biochem Mol Biol Int 1996
(Leukemia, Erythroblastic, Acute) :
GM-CSF induces the tyrosine phosphorylation of three isoforms of Shc and its association with
Grb2 in TF-1 cell
Ward et al., Biochim Biophys Acta 1998
:
In this report, we show rapid phosphorylation of Shc upon
stimulation of NFS-60 cells with
G-CSF , and inducible association of Shc and
Grb2 with the G-CSF-R in these cells