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ACE — ANGPT2

Text-mined interactions from Literome

Califf et al., Am Heart J 2000 (Heart Failure) : However, ACE inhibitors may not suppress Ang II activity over their entire dosing interval and, with long-term therapy, Ang II levels tend to return to normal
Chappell et al., Hypertension 2000 : The results of recent studies have demonstrated that angiotensin (Ang)- ( 1-7 ) contributes to the antihypertensive actions of either combined ACE/Ang II type 1 receptor blockade or ACE inhibition alone
Nilsson et al., Am J Physiol Regul Integr Comp Physiol 2000 (Abnormalities, Drug-Induced) : We have shown previously that neonatal inhibition of the RAS, either with ANG II type 1-receptor blockade or angiotensin converting enzyme (ACE) inhibition , induces irreversible renal abnormalities
Nagashima et al., Circulation 2001 (Aortic Diseases...) : Accelerated ACE dependent Ang II formation and signaling via upregulated AT2R play a pivotal role in VSMC apoptosis in CMD, and the ACE inhibitor could have clinical value in the prevention and treatment of CMD
Pepine et al., Clin Cardiol 2001 (Arteriosclerosis...) : In the renin-angiotensin system, angiotensin converting enzyme (ACE) mediates generation of angiotensin II (ang II) at local vascular sites and in the plasma and also degrades bradykinin
Friedrich et al., J Renin Angiotensin Aldosterone Syst 2003 (Hypertension...) : Ang II plays a key role in pressure independent mechanisms causing LVH, and angiotensin converting enzyme (ACE) inhibitors induce more pronounced LVH regression than some other antihypertensives
Raasch et al., J Hypertens 2005 : The functional relevance of ACE dependent and NEP dependent generation and degradation of ANG II on NA overflow was determined in pithed rats by applications of ANG I ( 0.1-100 microg/kg ) or ANG II ( 0.01-10 microg/kg ) after single injections of ramipril ( 1 mg/kg ), the NEP inhibitor candoxatril ( 100 mg/kg ), or the vasopeptidase inhibitor omapatrilat ( 30 mg/kg )
Miyazaki et al., J Pharmacol Sci 2006 : On the way to clarifying the roles of the vascular ACE, we noticed that vascular Ang II production was not completely suppressed by ACE inhibitor alone
Mitchell et al., Ren Physiol Biochem 1991 : These findings indicate that intrarenal conversion of ANG I to ANG II occurs, at least in part, at a site which is inaccessible to acutely administered ACE inhibitors, or that there is an alternative pathway for the intrarenal conversion of ANG I to ANG II that is not blocked by ACE inhibitors
Yusof et al., Am J Physiol Heart Circ Physiol 2007 (Disease Models, Animal...) : Using an intravital microscopic approach in C57BL/6J mice, we showed that ANG II type I ( AT(1) ) or type II ( AT(2) ) receptor antagonism ( with valsartan or PD-123319, respectively ), inhibition of angiotensin converting enzyme (ACE) with captopril, or calcitonin gene related peptide (CGRP) receptor blockade ( CGRP8-37 ) prevented postischemic LR but did not influence I/R induced LA
Lavrentyev et al., Circ Res 2007 : Although HG did not affect the rate of angiotensinogen conversion, it decreased expression of angiotensin converting enzyme (ACE), downregulated ACE dependent Ang II generation, and upregulated rat vascular chymase dependent Ang II generation
Coppo et al., Regul Pept 2008 : This study was aimed at investigating the effects of Angiotensin ( Ang ) II stimulation on T lymphocytes mRNA expression of angiotensinogen (AGTN), angiotensin converting enzyme (ACE) and AT1-receptor ( R ) and on ACE activity and Ang II content
Nadu et al., Journal of the American Society of Hypertension : JASH 2008 : Moreover, TGR ( A1-7 ) 3292 presented lower Ang II levels and angiotensinogen expression and a higher angiotensin converting enzyme 2 (ACE2) expression in LV. Isoproterenol treatment increased cardiac Ang II concentration only in normal rats, which was associated with an increase in ACE2 and a decrease in Mas expression
Fernandes et al., Hypertension 2011 (Hypertrophy, Left Ventricular) : Cardiac Ang I levels, Ang converting enzyme (ACE) activity, and protein expression, as well as Ang II levels, were lower in T1 and T2 ; however, Ang II type 1 receptor mRNA levels ( 69 % in T1 and 99 % in T2 ) and protein expression ( 240 % in T1 and 300 % in T2 ) increased after training
Jin et al., PloS one 2012 (Inflammation) : Furthermore, ACE2 deficiency led to greater increases in Ang II-mediated profilin-1 expression, NADPH oxidase activity, and superoxide and peroxynitrite production in the aortas of ACE2KO mice associated with enhanced phosphorylated levels of Akt, p70S6 kinase, extracellular signal regulated kinases ( ERK1/2 ) and endothelial nitric oxide synthase (eNOS)
Xiao et al., Am J Physiol Cell Physiol 2013 (MAP Kinase Signaling System) : ANG II induced a significant dose dependent increase in ACE and decrease in ACE2 mRNA and protein expression in CATH.a neurons ... These data suggest that ANG II increases ACE and attenuates ACE2 expression in neurons via the ANG II type 1 receptor, p38 MAPK, and ERK1/2 signaling pathways
Hilgers et al., J Hypertens 1989 : The renin inhibitor H-142 abolished all effects of renin whereas ACE inhibition prevented Ang II formation and vasoconstriction but increased Ang I levels
Rakugi et al., J Clin Invest 1994 : Since tissue ACE plays a key role in the control of local Ang II production, we examined whether vascular injury resulted in an increase in vascular ACE expression that may result in increased Ang II production
Kokkonen et al., Circulation 1997 : Data from in vitro studies suggest that both chymase and ACE contribute to the local generation of angiotensin (Ang) II in the heart
Davis et al., Pharmacol Ther 1997 (Heart Diseases) : The generation of Ang II involves angiotensin converting enzyme (ACE) in circulating and tissue RAS 's, as well as non-ACE pathways
Ménard et al., Circulation 1997 (Hypertension) : When both drugs are given together, the ACE inhibitor induced fall in plasma Ang II results in modulation of the Ang II antagonist induced reactive rise in Ang II , thereby lowering the plasma Ang II concentration, which competes with the antagonist for the Ang II receptors